Douglas

Douglas DIM Enhanced is a microencapsulated form of diindolylmethane (DIM) designed to promote healthy estrogen balance. Standardized curcumin and green tea extracts are also included alongside wasabia.

Healthy hormone detoxification is a crucial part of the normal functioning of organs, including the breast. DIM is known to help stimulate natural detoxification enzymes and support healthy estrogen metabolism. As a natural component derived from indole-3-carbinole and cruciferous vegetables, DIM has been shown in clinical research to favour the production of the estrogen metabolite 2-hydroxyestrone over the more deleterious 16-hydroxyestrone. DIM can also decrease the severity and duration of recurrent breast pain and promote antioxidant support. Microencapsulated DIMÂ by BioResponse is a patented, absorption-enhancing formulation to ensure proper assimilation by the body. It is the only DIM with proven absorption and activity demonstrated in independently performed clinical studies.

Polyphenols in green tea, specifically the catechins, provide the primary health promoting benefits associated with green tea consumption. Catechins, most notably epigallocatechin gallate (EGCG), are effective antioxidants and decrease harmful oxidative damage. Studies have shown that curcuminoids, naturally occurring bioactive compounds from turmeric, also scavenge free radicals by providing antioxidants. Since curcumin exhibits poor absorption when consumed orally, DIMÂ Enhanced contains a highly bioavailable curcumin that has up to a 20-fold improvement in bioavailability versus the standard 95% curcumin extracts.

Wasabia japonica (a member of the cruciferous vegetable family) contains long chain isothiocyanates (ITCs), which are unique to wasabia.

NPN: 80064554

• Helps to support/promote healthy estrogen metabolism/balance
• Helps reduce the severity and duration of symptoms associated with recurrent breast pain

Douglas Estro-Mend is a soy-free blend of herbs used in herbal medicine that helps ease nervous tension while relieving pain associated with menstruation and symptoms associated with menopause.

A complex interaction of hormones regulates menstruation. Imbalances of hormones, including estrogen, can result in menstrual pain and premenstrual symptoms, which often include changes in mood, energy, attention, appetite, sleep, physical comfort (breast tenderness, bloating) and quality of life. Phytoestrogens, including black cohosh, mimic the functions of estrogens without proliferative actions and help relieve menstrual pain and premenstrual symptoms.

Significantly less estrogen is produced in the period before menopause. Hormonal fluctuations during this time can result in common menopausal symptoms, including hot flushes and vaginal dryness. Phytoestrogens also support and minimize the changes and symptoms that are sometimes experienced during menopause. Studies have found that black cohosh helps relieve menopausal symptoms, such as hot flushes, excessive sweating, insomnia, and vaginal atrophy. As menopause may result in sleep disruption, Estro-Mend also contains hops, which can relieve nervousness and aid sleep.

NPN: 80040917

• Used in herbal medicine to help relieve premenstrual symptoms and pain associated with menstruation and helps to relieve symptoms associated with menopause

Douglas Zinc Lozenges supply bioavailable zinc, sweetened with sorbitol and flavored with natural orange extracts. Each tablet contains 10mg of elemental zinc in the form of zinc citrate. Zinc is an essential trace element involved in most major metabolic pathways and has important functions in maintaining immune function, healthy skin, and tissue formation. Numerous studies support the fundamental role of zinc in normal immune response in humans.

Immune cells must be able to rapidly divide in order to respond to daily challenges. Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. Similarly, zinc is required to maintain healthy skin as a component of matrix metalloproteinases. These enzymes break down matrix proteins, including collagen and elastin, which helps in skin remodeling and repair.

NPN: 80032476

•  Helps to maintain immune function

Brain Calm is an effective blend of critical amino acids and herbs that promote relaxation and sleep. GABA (gamma-aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the brain. Most neurotransmitters, such as acetylcholine and noradrenaline, promote a feeling of wakefulness and alertness, however GABA acts by blocking these –excitatory” neurotransmitters to promote relaxation in the brain.

By promoting relaxation, GABA has been shown to help sleep irregularities such as the inability to fall asleep or waking during the night. Additionally, Brain Calm contains Passion flower, which is used traditionally in Herbal Medicine as a sleep aid, especially in times of restlessness or sleeplessness due to mental stress. Plant compounds of Passion flower exert effects in the brain by binding to GABA receptors, promoting a relaxation effect similar to GABA itself.

By reducing feelings of anxiousness and stress, randomized control trials have found that Passion flower improves overall sleep quality.

NPN: 80031289

• Temporarily promotes relaxation
• Passionflower is traditionally used in herbal medicine as a sleep aid

Douglas Opti-Zinc supplies zinc monomethionine, a patented organic compound that combines zinc and the amino acid methionine to increase the bioavailability of zinc. Human and animal studies show that zinc monomethionine, as supplied by Opti-Zinc 30, is absorbed and retained better than many other forms of zinc.

Zinc is an essential trace element involved in most major metabolic pathways. General signs of human zinc deficiency indicate that zinc has important functions in maintaining immune function, healthy skin and growth. Numerous studies support the fundamental role of zinc for normal immune response in humans. Immune cells must be able to rapidly divide in order to respond to daily challenges.

Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. Similarly, zinc is required to maintain healthy skin as a component of matrix metalloproteinases. These enzymes break down matrix proteins, including collagen and elastin, which helps in skin remodeling and repair.

NPN: 80001176

• Helps to maintain healthy bones, hair, nails, and skin
• Helps to maintain immune function

Testo-Plus is a unique mixture of herbs, including Siberian and Panax ginseng, that provide support for mental and physical performance after stress. Research has found that stress may lower testosterone levels in both men and women in a variety of ways:
1. Stress increases oxidative damage, which decreases the production of steroid hormones.
2. The stress hormone cortisol prevents testosterone secretion.
3. Stress inhibits the synthesis and release of luteinizing hormone-releasing hormone (LHRH), decreasing the production of luteinizing hormone (the hormone responsible for testosterone production in the testis).
4. Stress decreases blood flow to the testicles, which lowers testosterone levels. 5. Stress negatively affects norepinephrine, which is involved in the production of LHRH in both men and women as well as testosterone synthesis in males.

Siberian ginseng improves mental and physical performance after exertion by regulating the signalling of hormones involved in stress responses, including cortisol and norepinephrine. This promotes proper hypothalamic-pituitary-adrenal (HPA) axis function, which controls various homeostatic processes in the body. Similarly, panax ginseng supports the body’s response to stress and fatigue. It is also a supportive therapy for the promotion of healthy glucose levels. Ginseng’s actions in the body are thought to be due to a complex interplay of constituents, including ginsenosides.

NPN: 80041849

•  Helps support cognitive function and reduce mental fatigue
•  Used in herbal medicine to help improve mental and physical performance after periods of mental or physical exertion
•  Provides antioxidants.

Douglas Melatonin sublingual tablets each contain 3mg of high-purity melatonin. Purity and potency of each batch of Melatonin tablets are verified by an independent, certified analytical laboratory.

Melatonin is a hormone synthesized from the amino acid tryptophan by the pineal gland in the brain. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in a dark environment, the body’s melatonin production rises, which is thought to be responsible for promoting sleep. Therefore, most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms.

Research has shown that melatonin supplementation helps reset the body’s sleep-wake cycle, an aspect of the circadian rhythm. It helps reduce the time it takes to fall asleep (sleep onset latency) in people with delayed sleep phase disorder, who often experience difficulty falling asleep at desired or conventional times. Melatonin also increases the total sleep time in people suffering from sleep restriction or altered sleep schedule, including shift-work and jet lag, and helps to relieve the daytime fatigue associated with jet lag.

Nocturnal melatonin production is highest in children and begins to decline from adolescence until it is virtually absent in the elderly. This sublingual tablet will rapidly dissolve when placed under the tongue and the bisect tablet allows for easy dosing modifications. 

NPN: 80001069

•  Helps increase the total sleep time in people from suffering sleep restriction or altered sleep schedule

Douglas Sereniten Plus contains milk protein hydrolysate, which temporarily helps reduce symptoms of mild mental and physical stress. The milk protein hydrolysate, in the form of Lactium, contains a bioactive decapeptide that has been clinically studied for reducing stress.

During times of physical or mental stress, cortisol levels in the body rise as a defensive mechanism to protect the body. Although this is an adaptive mechanism, prolonged secretion of cortisol can have negative impacts on proper functioning, including reduced immune function and poor digestion.

In participants subject to induced stress, one randomized control study found that alpha S1-casein hydrolysate, the active peptide of Lactium, decreased plasma cortisol levels and lowered heart rate compared to controls. Another study found that alpha S1-casein hydrolysate also improved feelings of well-being and digestion among stressed women. 

Sereniten Plus also contains L-theanine and vitamin D. Vitamin D is a factor in sustaining good health and helps in the maintenance of bones and teeth.

NPN: 80061493

• Helps temporarily reduce symptoms of mild mental and physical stress