Douglas DIM Enhanced is a microencapsulated form of diindolylmethane (DIM) designed to promote healthy estrogen balance. Standardized curcumin and green tea extracts are also included alongside wasabia.

Healthy hormone detoxification is a crucial part of the normal functioning of organs, including the breast. DIM is known to help stimulate natural detoxification enzymes and support healthy estrogen metabolism. As a natural component derived from indole-3-carbinole and cruciferous vegetables, DIM has been shown in clinical research to favour the production of the estrogen metabolite 2-hydroxyestrone over the more deleterious 16-hydroxyestrone. DIM can also decrease the severity and duration of recurrent breast pain and promote antioxidant support. Microencapsulated DIMÂ by BioResponse is a patented, absorption-enhancing formulation to ensure proper assimilation by the body. It is the only DIM with proven absorption and activity demonstrated in independently performed clinical studies.

Polyphenols in green tea, specifically the catechins, provide the primary health promoting benefits associated with green tea consumption. Catechins, most notably epigallocatechin gallate (EGCG), are effective antioxidants and decrease harmful oxidative damage. Studies have shown that curcuminoids, naturally occurring bioactive compounds from turmeric, also scavenge free radicals by providing antioxidants. Since curcumin exhibits poor absorption when consumed orally, DIMÂ Enhanced contains a highly bioavailable curcumin that has up to a 20-fold improvement in bioavailability versus the standard 95% curcumin extracts.

Wasabia japonica (a member of the cruciferous vegetable family) contains long chain isothiocyanates (ITCs), which are unique to wasabia.

NPN: 80064554

• Helps to support/promote healthy estrogen metabolism/balance
• Helps reduce the severity and duration of symptoms associated with recurrent breast pain

Douglas Zinc Lozenges supply bioavailable zinc, sweetened with sorbitol and flavored with natural orange extracts. Each tablet contains 10mg of elemental zinc in the form of zinc citrate. Zinc is an essential trace element involved in most major metabolic pathways and has important functions in maintaining immune function, healthy skin, and tissue formation. Numerous studies support the fundamental role of zinc in normal immune response in humans.

Immune cells must be able to rapidly divide in order to respond to daily challenges. Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. Similarly, zinc is required to maintain healthy skin as a component of matrix metalloproteinases. These enzymes break down matrix proteins, including collagen and elastin, which helps in skin remodeling and repair.

NPN: 80032476

•  Helps to maintain immune function

Douglas Estro-Mend is a soy-free blend of herbs used in herbal medicine that helps ease nervous tension while relieving pain associated with menstruation and symptoms associated with menopause.

A complex interaction of hormones regulates menstruation. Imbalances of hormones, including estrogen, can result in menstrual pain and premenstrual symptoms, which often include changes in mood, energy, attention, appetite, sleep, physical comfort (breast tenderness, bloating) and quality of life. Phytoestrogens, including black cohosh, mimic the functions of estrogens without proliferative actions and help relieve menstrual pain and premenstrual symptoms.

Significantly less estrogen is produced in the period before menopause. Hormonal fluctuations during this time can result in common menopausal symptoms, including hot flushes and vaginal dryness. Phytoestrogens also support and minimize the changes and symptoms that are sometimes experienced during menopause. Studies have found that black cohosh helps relieve menopausal symptoms, such as hot flushes, excessive sweating, insomnia, and vaginal atrophy. As menopause may result in sleep disruption, Estro-Mend also contains hops, which can relieve nervousness and aid sleep.

NPN: 80040917

• Used in herbal medicine to help relieve premenstrual symptoms and pain associated with menstruation and helps to relieve symptoms associated with menopause

Testo-Plus is a unique mixture of herbs, including Siberian and Panax ginseng, that provide support for mental and physical performance after stress. Research has found that stress may lower testosterone levels in both men and women in a variety of ways:
1. Stress increases oxidative damage, which decreases the production of steroid hormones.
2. The stress hormone cortisol prevents testosterone secretion.
3. Stress inhibits the synthesis and release of luteinizing hormone-releasing hormone (LHRH), decreasing the production of luteinizing hormone (the hormone responsible for testosterone production in the testis).
4. Stress decreases blood flow to the testicles, which lowers testosterone levels. 5. Stress negatively affects norepinephrine, which is involved in the production of LHRH in both men and women as well as testosterone synthesis in males.

Siberian ginseng improves mental and physical performance after exertion by regulating the signalling of hormones involved in stress responses, including cortisol and norepinephrine. This promotes proper hypothalamic-pituitary-adrenal (HPA) axis function, which controls various homeostatic processes in the body. Similarly, panax ginseng supports the body’s response to stress and fatigue. It is also a supportive therapy for the promotion of healthy glucose levels. Ginseng’s actions in the body are thought to be due to a complex interplay of constituents, including ginsenosides.

NPN: 80041849

•  Helps support cognitive function and reduce mental fatigue
•  Used in herbal medicine to help improve mental and physical performance after periods of mental or physical exertion
•  Provides antioxidants.

Brain Calm is an effective blend of critical amino acids and herbs that promote relaxation and sleep. GABA (gamma-aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the brain. Most neurotransmitters, such as acetylcholine and noradrenaline, promote a feeling of wakefulness and alertness, however GABA acts by blocking these –excitatory” neurotransmitters to promote relaxation in the brain.

By promoting relaxation, GABA has been shown to help sleep irregularities such as the inability to fall asleep or waking during the night. Additionally, Brain Calm contains Passion flower, which is used traditionally in Herbal Medicine as a sleep aid, especially in times of restlessness or sleeplessness due to mental stress. Plant compounds of Passion flower exert effects in the brain by binding to GABA receptors, promoting a relaxation effect similar to GABA itself.

NPN: 80031289

• Temporarily promotes relaxation
• Passionflower is traditionally used in herbal medicine as a sleep aid

Douglas Melatonin sublingual tablets each contain 3mg of high-purity melatonin. Purity and potency of each batch of Melatonin tablets are verified by an independent, certified analytical laboratory.

Melatonin is a hormone synthesized from the amino acid tryptophan by the pineal gland in the brain. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in a dark environment, the body’s melatonin production rises, which is thought to be responsible for promoting sleep. Therefore, most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms.

Research has shown that melatonin supplementation helps reset the body’s sleep-wake cycle, an aspect of the circadian rhythm. It helps reduce the time it takes to fall asleep (sleep onset latency) in people with delayed sleep phase disorder, who often experience difficulty falling asleep at desired or conventional times. Melatonin also increases the total sleep time in people suffering from sleep restriction or altered sleep schedule, including shift-work and jet lag, and helps to relieve the daytime fatigue associated with jet lag.

Nocturnal melatonin production is highest in children and begins to decline from adolescence until it is virtually absent in the elderly. This sublingual tablet will rapidly dissolve when placed under the tongue and the bisect tablet allows for easy dosing modifications. 

NPN: 80001069

•  Helps increase the total sleep time in people from suffering sleep restriction or altered sleep schedule

Douglas Opti-Zinc supplies zinc monomethionine, a patented organic compound that combines zinc and the amino acid methionine to increase the bioavailability of zinc. Human and animal studies show that zinc monomethionine, as supplied by Opti-Zinc 30, is absorbed and retained better than many other forms of zinc.

Zinc is an essential trace element involved in most major metabolic pathways. General signs of human zinc deficiency indicate that zinc has important functions in maintaining immune function, healthy skin and growth. Numerous studies support the fundamental role of zinc for normal immune response in humans. Immune cells must be able to rapidly divide in order to respond to daily challenges.

Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. Similarly, zinc is required to maintain healthy skin as a component of matrix metalloproteinases. These enzymes break down matrix proteins, including collagen and elastin, which helps in skin remodeling and repair.

NPN: 80001176

• Helps to maintain healthy bones, hair, nails, and skin
• Helps to maintain immune function

Melatonin PR provides all of the benefits of Melatonin in a convenient prolonged-release tablet.

NPN: 80027990

• Helps increase the total sleep time in people suffering from sleep restriction or altered sleep schedule and reset the body's sleep-wake cycle

Douglas Methyl B12 Plus by Douglas Laboratories provides Metafolin L-methylfolate and vitamin B12 methylcobalamin in a great-tasting lozenge that rapidly dissolves in the mouth.

Methylfolate and methylcobalamin are the predominant forms of B vitamins commonly found in cells that do not require additional conversion in the body. Methyl B12 Plus lozenges are sweetened naturally with xylitol, mannitol and flavoured with natural black cherry and vanilla.

NPN: 80027990

•  Increases their intake of vitamin B12 and folate 

Douglas Sereniten Plus contains milk protein hydrolysate, which temporarily helps reduce symptoms of mild mental and physical stress. The milk protein hydrolysate, in the form of Lactium, contains a bioactive decapeptide that has been clinically studied for reducing stress.

During times of physical or mental stress, cortisol levels in the body rise as a defensive mechanism to protect the body. Although this is an adaptive mechanism, prolonged secretion of cortisol can have negative impacts on proper functioning, including reduced immune function and poor digestion.

In participants subject to induced stress, one randomized control study found that alpha S1-casein hydrolysate, the active peptide of Lactium, decreased plasma cortisol levels and lowered heart rate compared to controls. Another study found that alpha S1-casein hydrolysate also improved feelings of well-being and digestion among stressed women. 

Sereniten Plus also contains L-theanine and vitamin D. Vitamin D is a factor in sustaining good health and helps in the maintenance of bones and teeth.

NPN: 80061493

• Helps temporarily reduce symptoms of mild mental and physical stress

Douglas Methyl Folate supplies 1000mcg of biologically active folate per tablet from Metafolin, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health. Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR). In certain populations, the body's ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.

Metafolin contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits, and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can prevent neural tube defects in the fetus. Additionally, folate plays a key role in red blood cell production and the formation of methionine.

NPN: 80034168

• Helps to reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy
• Helps to form red blood cells

Folate (calcium l-5 methyltetrahydrofolate, Metafolin) 1000mcg.

Non-Medicinal Ingredients:
Cellulose, dicalcium phosphate dihydrate, croscarmellose sodium, magnesium stearate, silica, and stearic acid.

Adults: Take 1 tablet daily or as directed by a healthcare practitioner. For use beyond 12 weeks, consult a healthcare practitioner.

Folate supplementation can mask vitamin B12 deficiency; consult your healthcare practitioner if you are uncertain whether or not you are taking adequate vitamin B12. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Adrenplus-300 supplies a combination of vitamins and minerals needed to maintain good health, plus adrenal and spleen glandular concentrate. The adrenal glands are endocrine glands located above the kidneys that are responsible for producing mineralocorticoids, glucocorticoids and androgens, as well as adrenaline and noradrenaline. The spleen is located in the upper-left abdomen and is primarily responsible for filtering blood.

As co-enzymes, B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of nutrients. B vitamins folate and B12 are also necessary for blood cell formation.

Zinc is an essential trace element required for the activity of over 300 enzymes and is involved in most major metabolic pathways. Vitamin A plays a critical role in maintaining eyesight and night vision through its role in the formation of the retinal pigment rhodopsin. Both zinc and vitamin A help maintain skin and immune health.

Adrenplus-300 also provides vitamin C, an important water-soluble antioxidant that protects cells from free radical damage. The adrenal glands contain some of the highest vitamin C levels in the body, and may require the antioxidant vitamin to quench free radicals produced during steroidogenesis.

NPN: 80040126

•  Helps to maintain eyesight, skin and immune function
•  Helps in the development of bones, cartilage, teeth, and gums
•  Helps in wound healing

Douglas Vita-Kids Immune provides important immune supportive nutrients for children in a great-tasting, natural grape-flavoured liquid. Free radicals are unstable compounds formed in the body during metabolism and from exposure to environmental sources such as pollution and cigarette smoke. Free radicals are necessary for energy metabolism and immune function, but when an excessive number of free radicals are formed, they can attack healthy cells, especially their membrane lipids and proteins.

This, in turn, is thought to affect a number of body processes, including optimal functioning of the immune system. Elderberry and blueberry extracts provide anthocyanins, important antioxidants that protect healthy cells from oxidative and free radical damage. Numerous studies have demonstrated the importance of beta-carotene for normal immune function. The immune benefits of beta-carotene are due to its role as a precursor to vitamin A, which stimulates the production of immune cells. Zinc is an essential trace element involved in most major metabolic pathways. Numerous studies also support the fundamental role of zinc in promoting normal immune responses in humans. Immune cells must be able to rapidly divide in order to respond to daily challenges, and they depend on adequate amounts of dietary zinc to promote their development.

Healthy immune function can also be maintained by supporting a well-balanced production of cytokines. However, low levels of zinc lead to decreased immune responses, including the production of fewer cytokines that target intracellular bacteria.

NPN: 80066279

•  Helps to maintain immune function

Magnesium is a mineral with a fundamentally important physiological function in the body and is essential in a wide range of fundamental cellular reactions. Complexed with adenosine triphosphate (ATP), the main carrier of metabolic energy in the body, magnesium is essential for all biosynthetic processes including the metabolism of carbohydrates, fats, and proteins along with proper muscle function.

Magnesium is also critical in the development and maintenance of bones and teeth. In a randomized control trial, supplementation with magnesium glycinate in pregnant women was shown to significantly decrease muscle cramping frequency and intensity.

NPN: 80029196

• Helps to maintain proper muscle function

Betaine Plus supplies the digestive enzymes betaine and pepsin in a convenient capsule form. Originally isolated from sugar beets, betaine can be found in a number of dietary sources including wheat, quinoa, and spinach.

Betaine is a catabolic source of methyl groups, involved in numerous metabolic processes throughout the body. Chief cells in the stomach release pepsinogen where then hydrochloric acid acts as a catalyst in the activation of pepsin from pepsinogen. Pepsin is key in the process of converting protein obtained through the diet into peptides the body can digest to use for energy and structural building.

NPN: 80036363

• Digestive Aid. Helps to support digestion.

Douglas Ascorbplex 1000 Buffered is a high potency vitamin C supplement specially buffered with calcium, magnesium, and potassium, which help to minimize stomach irritation associated with the acidity of many vitamin C preparations. Ascorbplex 1000 Buffered also contains bioflavonoids, which have been shown to increase the bioavailability of vitamin C in supplemental form compared to vitamin C taken alone.

Vitamin C is among the most powerful antioxidants in humans. Vitamin C is a water-soluble antioxidant that can react directly with superoxide and hydroxyl radicals to decrease potential damage to cells within the body. In addition, vitamin C interacts with glutathione and alpha-lipoic acid, and can regenerate the antioxidant potential of vitamin E. Vitamin C helps in the development and maintenance of bones, cartilage, teeth, and gums. In bone, Vitamin C helps form collagen in the bone matrix while scavenging free radicals that can be detrimental to bones. Vitamin C supplementation has been associated with increased bone mineral density and lower fracture probabilities in adults.

Vitamin C is also essential in the formation of connective tissue and aids in wound healing by decreasing proinflammatory responses and medicating proliferative and remodeling stages in the healing process.

NPN: 01997793

•  Provides antioxidants
•  Helps in connective tissue formation and wound healing

Douglas Ultrazyme was specifically formulated with bile and active digestive enzymes that assist in fat, protein and carbohydrate digestion in the stomach and small intestine. Although fat digestion starts in the mouth with salivary lipase, most triglycerides are digested by pancreatic lipase. Pancreatic lipase cleaves triglycerides into monoglycerides and free fatty acids, which are efficiently absorbed in the upper small intestine.

NPN: 80084139

•  Aids digestion by providing digestive enzymes further increasing nutrient bioavailability while minimizing antibody responses in the digestive tract

Pancreatic Enzymes/ Enzymes pancréatiques
(from pancreas of) 62.5 mg
Yielding/ Rendement:
Amylase 12 500 USP
Protease 12 500 USP
Lipase 1000 USP
Ox Bile 50 mg
L-Lysine (l-lysine monohydrochloride 40 mg
Pepsin 33 mg (330 000 FCC PU)
Stem Bromelain 25 mg (900 000 FCC PU)
Cellulase 3 mg (45 FCC CU)

Non-medicinal ingredients: Dicalcium phosphate dihydrate, cellulose, tablet coating (hypromellose, glycerin), croscarmellose sodium, stearic acid, magnesium

Non-Medicinal Ingredients:
Dicalcium phosphate dihydrate, cellulose, croscarmellose sodium, stearic acid, magnesium stearate, silica and tablet coating (hypromellose, glycerin).

Acetyl-L-carnitine, a naturally occurring metabolite of L-carnitine, plays a key role in supporting cognitive function during aging while helping to reduce fatigue. In most tissues of the body, both L-carnitine and acetyl-L-carnitine are involved in fatty acid oxidation. L-carnitine shuttles fatty acids from the cytosol (the cell fluid) into the mitochondria (the cell's powerhouses) for oxidation and energy production. In the brain, acetyl-L-carnitine specifically acts on fatty acid oxidation in astrocytes and neurons to produce energy.

The compound exerts its cognitive protective effects through three main actions. Acetyl-L-Carnitine protects tissues against oxidative stress while producing energy and influences the activity of nerve growth factor (NGF), the neuropeptide responsible for the growth, maintenance, and survival of certain neurons. It has also been shown that acetyl-L-carnitine can help to maintain cellular membrane stability and to restore age-related membranal changes.

NPN: 80070235

•  Supports cognitive function and brain function

LVDTX is a comprehensive blend of synergistic nutrients that support the health of the liver, an organ involved in detoxifying the blood, metabolizing fat and storing vitamins. Choline acts as an important methyl donor in numerous metabolic reactions. It is considered an essential nutrient needed for cell membrane integrity and to facilitate the movement of fats into and out of cells.

Choline is also a component of the neurotransmitter acetylcholine and is required for normal brain function. Choline is available as choline bitartrate (a soluble salt) or as phosphatidyl-choline in lecithin. Inositol has similar properties to choline in its lipotropic effect and is found in most cell membranes. Methionine is critical for hepatic intracellular concentrations of glutathione. Glutathione and other sulfhydryl peptides are essential in the detoxification of xenobiotic substances and in converting lipid soluble toxic agents to water soluble material for easy excretion via the kidneys. Betaine not only protects the liver from damage due to excess homocysteine, it also generates adenosylmethionine (SAM), which is the universal methyl donor. 

Turmeric contains curcumin, a naturally occurring biologically active group of compounds. Studies have shown that curcumin can function as efficient antioxidants and can help regulate the body's normal response to inflammatory processes. Turmeric, along with dandelion, milk thistle and artichoke, is traditionally used in herbal medicine.

NPN: 80030794

•  Supports cognitive function and brain function

Vitamin K2 supplies a significant amount of biologically active vitamin K in the form of menaquinone-7 (MK-7). Beyond blood clotting, the role of vitamin K in osteoporosis is related to calcium utilization. Scientific studies have revealed that vitamin K is required for the carboxylation of osteocalcin, a protein secreted by osteoblasts that regulates calcification and bone mineral maturation. Thus, vitamin K plays a crucial role in building and maintaining strong bones.

Vitamin K2 (as MK-7) is more bioactive and has proven more effective than vitamin K1 and other menaquinones. MK-7 showed eight times the half-life of vitamin K1 in a 24-hour serum concentration. Therefore, MK-7 can be administered in low dosages only once a day, typically 1/1000 of a MK-4 dose. Furthermore, the study showed better utilization and improved osteocalcin carboxylation for MK-7 after 6 weeks. Numerous studies reveal long-chain menaquinones, such as MK-7, are more effective in supporting arterial health than vitamin K1 menaquinones. Douglas Labs' Vitamin K2 (as MK-7) is derived from geraniol and farnesol. Geraniol is the primary part of rose, palmarosa and citronella oils.

Farnesol is also present in many essential oils such as citronella, lemon grass, rose and musk. This natural form of MK-7 has been extensively tested for molecular identity and bioequivalence when compared to MK-7 from fermented soybeans (natto). It is the all-trans form, thus providing a significantly higher purity of the only biologically active form.

NPN: 80026637

•  Helps in the maintenance of bones

• Helps to enhance memory and cognitive function in adults

Douglas Relora-Plex is a unique blend of two herbal extracts, Magnolia officinalis and Phellodendron amurense, combined with B vitamins for the maintenance of good health. Magnolia officinalis and Phellodendron amurense are used in traditional Herbal Medicine to temporarily relieve symptoms of perceived stress. When the body experiences stress, cortisol secretion increases, causing a breakdown of muscle protein and the release of amino acids to form glucose via gluconeogenesis.

The resulting higher level of glucose in the body, combined with the decreased use of glucose by other tissues, ensures that the brain is receiving adequate energy to protect the body. While cortisol secretion is an important part of the body's response to stress, the prolonged secretion of cortisol can have negative effects to the proper functioning of the body including immune function, digestion, and hormones.

The extracts of Magnolia officinalis and Phellodendron amurense, honokiol and berberine, found in Relora, have been studied in randomized clinical trials showing positive results in reducing perceived stress. Both honokiol and berberine are known to have an anxiolytic effect on the body, decreasing stress and feelings of anxiousness that usually accompany stress. In a randomized control trial conducted on moderately stressed adults, Relora was shown to decrease salivary cortisol exposure indicating a reduction in cortisol released from the adrenal glands. Participants also reported a reduction in feelings of stress and improvements in sleep disturbances and restlessness attributed to stress. Relora allows individuals to feel less stress without causing drowsiness throughout the day.

NPN: 80028378

•  Temporarily relieves symptoms of perceived stress
•  Helps to form red blood cells

d-Mannose is a simple sugar found naturally in fruits such as cranberries and pineapples. It is absorbed slowly from the gastrointestinal tract and unlike many sugars, it is not converted into glycogen or stored in the liver.

Much of the d-Mannose consumed is filtered by the kidneys and delivered to the bladder, where it is excreted in the urine. Daily supplementation with d-Mannose is a great alternative to drinking cranberry juice as cranberry juice frequently contains high levels of fructose and is not often standardized to d-Mannose concentrations.

NPN: 80035223

• Athletic support
• Source of carbohydrates to support energy production