Douglas

Douglas Estro-Mend is a soy-free blend of herbs used in herbal medicine that helps ease nervous tension while relieving pain associated with menstruation and symptoms associated with menopause.

A complex interaction of hormones regulates menstruation. Imbalances of hormones, including estrogen, can result in menstrual pain and premenstrual symptoms, which often include changes in mood, energy, attention, appetite, sleep, physical comfort (breast tenderness, bloating) and quality of life. Phytoestrogens, including black cohosh, mimic the functions of estrogens without proliferative actions and help relieve menstrual pain and premenstrual symptoms.

Significantly less estrogen is produced in the period before menopause. Hormonal fluctuations during this time can result in common menopausal symptoms, including hot flushes and vaginal dryness. Phytoestrogens also support and minimize the changes and symptoms that are sometimes experienced during menopause. Studies have found that black cohosh helps relieve menopausal symptoms, such as hot flushes, excessive sweating, insomnia, and vaginal atrophy. As menopause may result in sleep disruption, Estro-Mend also contains hops, which can relieve nervousness and aid sleep.

NPN: 80040917

• Used in herbal medicine to help relieve premenstrual symptoms and pain associated with menstruation and helps to relieve symptoms associated with menopause

Douglas Opti-Zinc supplies zinc monomethionine, a patented organic compound that combines zinc and the amino acid methionine to increase the bioavailability of zinc. Human and animal studies show that zinc monomethionine, as supplied by Opti-Zinc 30, is absorbed and retained better than many other forms of zinc.

Zinc is an essential trace element involved in most major metabolic pathways. General signs of human zinc deficiency indicate that zinc has important functions in maintaining immune function, healthy skin and growth. Numerous studies support the fundamental role of zinc for normal immune response in humans. Immune cells must be able to rapidly divide in order to respond to daily challenges.

Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. Similarly, zinc is required to maintain healthy skin as a component of matrix metalloproteinases. These enzymes break down matrix proteins, including collagen and elastin, which helps in skin remodeling and repair.

NPN: 80001176

• Helps to maintain healthy bones, hair, nails, and skin
• Helps to maintain immune function

Testo-Plus is a unique mixture of herbs, including Siberian and Panax ginseng, that provide support for mental and physical performance after stress. Research has found that stress may lower testosterone levels in both men and women in a variety of ways:
1. Stress increases oxidative damage, which decreases the production of steroid hormones.
2. The stress hormone cortisol prevents testosterone secretion.
3. Stress inhibits the synthesis and release of luteinizing hormone-releasing hormone (LHRH), decreasing the production of luteinizing hormone (the hormone responsible for testosterone production in the testis).
4. Stress decreases blood flow to the testicles, which lowers testosterone levels. 5. Stress negatively affects norepinephrine, which is involved in the production of LHRH in both men and women as well as testosterone synthesis in males.

Siberian ginseng improves mental and physical performance after exertion by regulating the signalling of hormones involved in stress responses, including cortisol and norepinephrine. This promotes proper hypothalamic-pituitary-adrenal (HPA) axis function, which controls various homeostatic processes in the body. Similarly, panax ginseng supports the body’s response to stress and fatigue. It is also a supportive therapy for the promotion of healthy glucose levels. Ginseng’s actions in the body are thought to be due to a complex interplay of constituents, including ginsenosides.

NPN: 80041849

•  Helps support cognitive function and reduce mental fatigue
•  Used in herbal medicine to help improve mental and physical performance after periods of mental or physical exertion
•  Provides antioxidants.

Douglas Chromium-GTF is a trace element supplement that contains chromium bound to nicotinic acid (chromium poly-nicotinate). Each capsule provides 200 mcg of chromium in its non-toxic trivalent form. Once in the body, the biologically active form of chromium is also referred to as glucose tolerance factor (GTF) as chromium provides support for healthy glucose metabolism. Although the exact mechanism is unknown, it is suggested that chromium interacts with the amino acids glycine, cysteine, glutamate, and aspartic acid in the form of low-molecular-weight chromium (LMWCr) binding substance, which then attaches to insulin receptors in the body when there is a spike of insulin in the body.

Chromium is generally accepted as an essential trace mineral that potentiates insulin action and thus influences carbohydrate and fat metabolism. Chromium absorption is typically less than 2% efficient and variable depending on its form. Studies have demonstrated that chromium from Chromium-GTF has a higher bioavailability than other chromium compounds, such as chromium picolinate or chloride. Furthermore, tissues retained anywhere from 2 to 8 times more chromium from Chromium-GTF compared to other sources.

NPN: 01992619

•  Provides support for healthy glucose metabolism 

Douglas Zinc Lozenges supply bioavailable zinc, sweetened with sorbitol and flavored with natural orange extracts. Each tablet contains 10mg of elemental zinc in the form of zinc citrate. Zinc is an essential trace element involved in most major metabolic pathways and has important functions in maintaining immune function, healthy skin, and tissue formation. Numerous studies support the fundamental role of zinc in normal immune response in humans.

Immune cells must be able to rapidly divide in order to respond to daily challenges. Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. Similarly, zinc is required to maintain healthy skin as a component of matrix metalloproteinases. These enzymes break down matrix proteins, including collagen and elastin, which helps in skin remodeling and repair.

NPN: 80032476

•  Helps to maintain immune function

Brain Calm is an effective blend of critical amino acids and herbs that promote relaxation and sleep. GABA (gamma-aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the brain. Most neurotransmitters, such as acetylcholine and noradrenaline, promote a feeling of wakefulness and alertness, however GABA acts by blocking these –excitatory” neurotransmitters to promote relaxation in the brain.

By promoting relaxation, GABA has been shown to help sleep irregularities such as the inability to fall asleep or waking during the night. Additionally, Brain Calm contains Passion flower, which is used traditionally in Herbal Medicine as a sleep aid, especially in times of restlessness or sleeplessness due to mental stress. Plant compounds of Passion flower exert effects in the brain by binding to GABA receptors, promoting a relaxation effect similar to GABA itself.

By reducing feelings of anxiousness and stress, randomized control trials have found that Passion flower improves overall sleep quality.

NPN: 80031289

• Temporarily promotes relaxation
• Passionflower is traditionally used in herbal medicine as a sleep aid

Douglas Sereniten Plus contains milk protein hydrolysate, which temporarily helps reduce symptoms of mild mental and physical stress. The milk protein hydrolysate, in the form of Lactium, contains a bioactive decapeptide that has been clinically studied for reducing stress.

During times of physical or mental stress, cortisol levels in the body rise as a defensive mechanism to protect the body. Although this is an adaptive mechanism, prolonged secretion of cortisol can have negative impacts on proper functioning, including reduced immune function and poor digestion.

In participants subject to induced stress, one randomized control study found that alpha S1-casein hydrolysate, the active peptide of Lactium, decreased plasma cortisol levels and lowered heart rate compared to controls. Another study found that alpha S1-casein hydrolysate also improved feelings of well-being and digestion among stressed women. 

Sereniten Plus also contains L-theanine and vitamin D. Vitamin D is a factor in sustaining good health and helps in the maintenance of bones and teeth.

NPN: 80061493

• Helps temporarily reduce symptoms of mild mental and physical stress

Douglas Melatonin sublingual tablets each contain 3mg of high-purity melatonin. Purity and potency of each batch of Melatonin tablets are verified by an independent, certified analytical laboratory.

Melatonin is a hormone synthesized from the amino acid tryptophan by the pineal gland in the brain. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in a dark environment, the body’s melatonin production rises, which is thought to be responsible for promoting sleep. Therefore, most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms.

Research has shown that melatonin supplementation helps reset the body’s sleep-wake cycle, an aspect of the circadian rhythm. It helps reduce the time it takes to fall asleep (sleep onset latency) in people with delayed sleep phase disorder, who often experience difficulty falling asleep at desired or conventional times. Melatonin also increases the total sleep time in people suffering from sleep restriction or altered sleep schedule, including shift-work and jet lag, and helps to relieve the daytime fatigue associated with jet lag.

Nocturnal melatonin production is highest in children and begins to decline from adolescence until it is virtually absent in the elderly. This sublingual tablet will rapidly dissolve when placed under the tongue and the bisect tablet allows for easy dosing modifications. 

NPN: 80001069

•  Helps increase the total sleep time in people from suffering sleep restriction or altered sleep schedule

Melatonin PR provides all of the benefits of Melatonin in a convenient prolonged-release tablet.

NPN: 80027990

• Helps increase the total sleep time in people suffering from sleep restriction or altered sleep schedule and reset the body's sleep-wake cycle

Adrenplus-300 supplies a combination of vitamins and minerals needed to maintain good health, plus adrenal and spleen glandular concentrate. The adrenal glands are endocrine glands located above the kidneys that are responsible for producing mineralocorticoids, glucocorticoids and androgens, as well as adrenaline and noradrenaline. The spleen is located in the upper-left abdomen and is primarily responsible for filtering blood.

As co-enzymes, B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of nutrients. B vitamins folate and B12 are also necessary for blood cell formation.

Zinc is an essential trace element required for the activity of over 300 enzymes and is involved in most major metabolic pathways. Vitamin A plays a critical role in maintaining eyesight and night vision through its role in the formation of the retinal pigment rhodopsin. Both zinc and vitamin A help maintain skin and immune health.

Adrenplus-300 also provides vitamin C, an important water-soluble antioxidant that protects cells from free radical damage. The adrenal glands contain some of the highest vitamin C levels in the body, and may require the antioxidant vitamin to quench free radicals produced during steroidogenesis.

NPN: 80040126

•  Helps to maintain eyesight, skin and immune function
•  Helps in the development of bones, cartilage, teeth, and gums
•  Helps in wound healing

Douglas Vita-Kids Immune provides important immune supportive nutrients for children in a great-tasting, natural grape-flavoured liquid. Free radicals are unstable compounds formed in the body during metabolism and from exposure to environmental sources such as pollution and cigarette smoke. Free radicals are necessary for energy metabolism and immune function, but when an excessive number of free radicals are formed, they can attack healthy cells, especially their membrane lipids and proteins.

This, in turn, is thought to affect a number of body processes, including optimal functioning of the immune system. Elderberry and blueberry extracts provide anthocyanins, important antioxidants that protect healthy cells from oxidative and free radical damage. Numerous studies have demonstrated the importance of beta-carotene for normal immune function. The immune benefits of beta-carotene are due to its role as a precursor to vitamin A, which stimulates the production of immune cells. Zinc is an essential trace element involved in most major metabolic pathways. Numerous studies also support the fundamental role of zinc in promoting normal immune responses in humans. Immune cells must be able to rapidly divide in order to respond to daily challenges, and they depend on adequate amounts of dietary zinc to promote their development.

Healthy immune function can also be maintained by supporting a well-balanced production of cytokines. However, low levels of zinc lead to decreased immune responses, including the production of fewer cytokines that target intracellular bacteria.

NPN: 80066279

•  Helps to maintain immune function

Douglas Methyl B12 Plus by Douglas Laboratories provides Metafolin L-methylfolate and vitamin B12 methylcobalamin in a great-tasting lozenge that rapidly dissolves in the mouth.

Methylfolate and methylcobalamin are the predominant forms of B vitamins commonly found in cells that do not require additional conversion in the body. Methyl B12 Plus lozenges are sweetened naturally with xylitol, mannitol and flavoured with natural black cherry and vanilla.

NPN: 80027990

•  Increases their intake of vitamin B12 and folate 

Douglas Methyl Folate supplies 1000mcg of biologically active folate per tablet from Metafolin, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health. Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR). In certain populations, the body's ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.

Metafolin contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits, and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can prevent neural tube defects in the fetus. Additionally, folate plays a key role in red blood cell production and the formation of methionine.

NPN: 80034168

• Helps to reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy
• Helps to form red blood cells

Folate (calcium l-5 methyltetrahydrofolate, Metafolin) 1000mcg.

Non-Medicinal Ingredients:
Cellulose, dicalcium phosphate dihydrate, croscarmellose sodium, magnesium stearate, silica, and stearic acid.

Adults: Take 1 tablet daily or as directed by a healthcare practitioner. For use beyond 12 weeks, consult a healthcare practitioner.

Folate supplementation can mask vitamin B12 deficiency; consult your healthcare practitioner if you are uncertain whether or not you are taking adequate vitamin B12. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Douglas Ascorbplex 1000 Buffered is a high potency vitamin C supplement specially buffered with calcium, magnesium, and potassium, which help to minimize stomach irritation associated with the acidity of many vitamin C preparations. Ascorbplex 1000 Buffered also contains bioflavonoids, which have been shown to increase the bioavailability of vitamin C in supplemental form compared to vitamin C taken alone.

Vitamin C is among the most powerful antioxidants in humans. Vitamin C is a water-soluble antioxidant that can react directly with superoxide and hydroxyl radicals to decrease potential damage to cells within the body. In addition, vitamin C interacts with glutathione and alpha-lipoic acid, and can regenerate the antioxidant potential of vitamin E. Vitamin C helps in the development and maintenance of bones, cartilage, teeth, and gums. In bone, Vitamin C helps form collagen in the bone matrix while scavenging free radicals that can be detrimental to bones. Vitamin C supplementation has been associated with increased bone mineral density and lower fracture probabilities in adults.

Vitamin C is also essential in the formation of connective tissue and aids in wound healing by decreasing proinflammatory responses and medicating proliferative and remodeling stages in the healing process.

NPN: 01997793

•  Provides antioxidants
•  Helps in connective tissue formation and wound healing

Acetyl-L-carnitine, a naturally occurring metabolite of L-carnitine, plays a key role in supporting cognitive function during aging while helping to reduce fatigue. In most tissues of the body, both L-carnitine and acetyl-L-carnitine are involved in fatty acid oxidation. L-carnitine shuttles fatty acids from the cytosol (the cell fluid) into the mitochondria (the cell's powerhouses) for oxidation and energy production. In the brain, acetyl-L-carnitine specifically acts on fatty acid oxidation in astrocytes and neurons to produce energy.

The compound exerts its cognitive protective effects through three main actions. Acetyl-L-Carnitine protects tissues against oxidative stress while producing energy and influences the activity of nerve growth factor (NGF), the neuropeptide responsible for the growth, maintenance, and survival of certain neurons. It has also been shown that acetyl-L-carnitine can help to maintain cellular membrane stability and to restore age-related membranal changes.

NPN: 80070235

•  Supports cognitive function and brain function

Niacin can be obtained from niacinamide, an amide of niacin that is typically well tolerated and not associated with causing a –flushing” reaction.

Niacin occurs in the body as two metabolically active coenzymes, NAD (nicotinamide adenine dinucleotide) and NADP (NAD phosphate). Niacin has pervasive roles in energy-related and biosynthetic metabolic processes. At least 200 enzymes depend on these niacin cofactors. The NAD-dependent enzymes are involved in mostly catabolic, oxidative reactions that release energy from carbohydrate, fat and protein, whereas the NADP-dependent enzymes more commonly function in biosynthetic pathways of compounds such as fatty acids.

NPN: 80014920

•  Helps to prevent niacia deficiency
• Helps to maintain body's abiliy to metaboliz nutrients
• Helps in energy metabolism

The adrenal glands are located above the kidneys and release hormones that help the body respond to stress. AdrenoMend is designed to promote optimal function of the various homeostasis regulatory systems that work with the adrenal glands to maintain physiological function during both acute and chronic stress. This formulation includes a combination of ten highly valued herbal extracts. Schisandra is used in Herbal Medicine as an adaptogen to help increase energy and resistance to stress.

Along with Eleuthero, it helps support mental performance and physical working capacity, and helps promote the balanced response of the sympatho-adrenal-system (SAS) to the body’s acute reaction to a stressor. Similarly, Panax is used in Herbal Medicine to help reduce mental fatigue and enhance physical capacity. It is also used as a supportive therapy for the promotion of healthy glucose levels as it mediates the stress induced elevations of catecholamines and adrenaline-induced hyperglycemia.

To provide additional cognitive support, Ashwagandha and Bacopa are included for their traditional use in Ayurveda for memory enhancement. Ashwagandha is also traditionally used in Ayurveda as a rejuvenative tonic, sedative and sleep aid.

NPN: 80036999

•  To help relieve general physical debility and support cognitive function during times of stress

Schisandra chinensis seed ( standardized to 2% schisandrins) 62.5mg,
bacopa monnieri aerial parts (standardized to 20% bacosides) 65mg,
rhodiola rosea root (standardized to 5% rosavins and 2% salidrosides) 50mg,
eleutherococcus senticosus (eleuthero) root (standardized to 0.8% eleutherosides) 50mg,
magnolia officinalis bark (standardized to 5% honokiol)  50mg,
rehmannia glutinosa, root (7:1 extract) 50mg,
bupleurum falcatum, root (5:1 extract) 50mg,
panax ginseng root (standardized to 3% ginsenosides) 50mg,
plectranthus barbatus (forskohlii) root (standardized to 1% forskolin) 50mg
sensoril withania somnifera (ashwagandha) root and leaf (standardized to a minimum of 8% withanolide glycoside conjugates and 32% oligosaccharides) 62.5mg.

Non-Medicinal Ingredients:
Cellulose, dicalcium phosphate, magnesium stearate and silica.

Adults: Take 2 capsules two times daily one half hour before meals, or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 30 days.

Consult a healthcare practitioner prior to use if you are taking digoxin, hormone replacement therapy, birth control pills, thyroid, anti-depressant, blood thinning, or calcium channel blocker medications or if you have an acute infection, if symptoms persist or worsen, or if you have diabetes. Do not use if you are pregnant, breastfeeding if you have high blood pressure, bipolar spectrum disorder. Consumption of alcohol with other drugs or natural health products with sedative properties is not recommended. Some people may experience insomnia, irritability, anxiety, or headaches, in which case discontinue use. May cause gastrointestinal disturbances such as epigastric burning sensation and nausea. Hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use.

LVDTX is a comprehensive blend of synergistic nutrients that support the health of the liver, an organ involved in detoxifying the blood, metabolizing fat and storing vitamins. Choline acts as an important methyl donor in numerous metabolic reactions. It is considered an essential nutrient needed for cell membrane integrity and to facilitate the movement of fats into and out of cells.

Choline is also a component of the neurotransmitter acetylcholine and is required for normal brain function. Choline is available as choline bitartrate (a soluble salt) or as phosphatidyl-choline in lecithin. Inositol has similar properties to choline in its lipotropic effect and is found in most cell membranes. Methionine is critical for hepatic intracellular concentrations of glutathione. Glutathione and other sulfhydryl peptides are essential in the detoxification of xenobiotic substances and in converting lipid soluble toxic agents to water soluble material for easy excretion via the kidneys. Betaine not only protects the liver from damage due to excess homocysteine, it also generates adenosylmethionine (SAM), which is the universal methyl donor. 

Turmeric contains curcumin, a naturally occurring biologically active group of compounds. Studies have shown that curcumin can function as efficient antioxidants and can help regulate the body's normal response to inflammatory processes. Turmeric, along with dandelion, milk thistle and artichoke, is traditionally used in herbal medicine.

NPN: 80030794

•  Supports cognitive function and brain function