Ashwagandha (Withania somnifera), Siberian ginseng (Eleutherococcus senticosus), lavender (Lavandula angustifolia), and Rhodiola (Rhodiola Rosea) are herbs known for their adaptogenic and calming properties, and that mediate the effects of stress and fatigue. Adaptogens induce stress-protective benefits, mediated through regulation of homeostasis via several mechanisms of action associated with the hypothalamic-pituitary-adrenal axis. Ashwagandha has been found to limit the production of dopamine and other hormones in response to stress and acts as a GABA receptor agonist, all of which have the effect of reducing the overall stress response.

Siberian ginseng root contains eleutherosides known to have anti-fatigue and anti-stress effects, as well as immunomodulatory effects, and has been shown clinically to have therapeutic efficacy for chronic fatigue, stress, and improve athletic performance. Lavender oil is thought to act on both the central and sympathetic nervous system and clinically has been shown to have a calming and relaxing effect, promoting an improved sense of wellbeing. Rhodiola Rosea has been clinically shown to improve attention, cognitive function and mental performance, decrease the cortisol response to stress, and exert an anti-fatigue effect.