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BIOCLINIC ESTROVANTAGE EM 90VCAPS

In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestra...

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In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative. As such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women. Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events. Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption. It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.
• IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.
• In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients
• Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro
• Silymarin can down-regulate gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)
• Curcumin inhibits human breast cancer cell growth by mediating certain signalling cascades including the modulation of the NF-κB signalling pathway
• Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression
• Suitable for vegetarians/vegans 
Each serving (3 veg-capsules) contains:
Medicinal ingredients:
Calcium d-glucarate (d-glucaric acid calcium salt) 75mg, indole-3-carbinol (3-hydroxymethylindole) 75mg, green tea extract (camellia sinensis) (leaf) (80% catechins, 45% egcg*, <1% caffeine) 50mg, tomato extract (lycopersicon esculentum) (fruit) (5% lycopene) 50mg, broccoli powder (brassica oleracea var. italica) (aerial) (0.36% sulforaphane) 27.5mg, dim (3,3’-diindolylmethane) 25mg, turmeric extract (curcuma longa) (rhizome) (95% curcuminoids) 25mg, milk thistle extract (silybum marianum) (seed) (50–60% silymarin) 25mg and rosemary extract (rosmarinus officinalis) (leaf) 12.5mg.

Non-medicinal ingredients:
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant) and silica.
Adults: Take 3 capsules once per day with food or as directed by a health care practitioner. Consult a healthcare practitioner for use beyond 12 weeks.
Do not use if you are pregnant or breastfeeding, are taking any medication, or if you have iron deficiency. Consult a healthcare practitioner if you have gallstones or a bile duct obstruction, have stomach ulcers or excess stomach acids. Consult a healthcare practitioner prior to use if you are attempting to conceive, have low estrogen or symptoms of low estrogen, have or are pre-disposed to cancer, are taking antiplatelet medication or blood thinners, or have a liver disease or develop symptoms of liver trouble. Hypersensitivity/allergy is known to occur, in which case discontinue use. Keep out of reach of children.

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