As the second most abundant intracellular action and a cofactor for at least 300 metabolic reactions, magnesium is a critical regulator of numerous cellular functions, ion channels, signalling pathways, enzymes, and metabolic pathways including glycolysis, fatty acid oxidation and DNA synthesis. Substantial epidemiological evidence indicates that a low magnesium intake is quite common, and that it is associated with diverse pathological conditions, particularly metabolic and inflammatory disorders such as insulin resistance, obesity, diabetes and cardiovascular disease, but also to osteoporosis, and hypertension.
Recent research has highlighted magnesium’s important role in glucose homeostasis, as supplementation improves insulin sensitivity and regulates beta-cell function, while deficiency exacerbates chronic inflammatory stress, contributing to obesity and the metabolic syndrome. Supplementation reduces serum glucose, increases HDL levels and improves insulin sensitivity, even among those with normal magnesium levels, and in both diabetic and non-diabetic populations. Magnesium also improves postprandial hyperlipidemia, and down-regulates genes related to metabolic and inflammatory pathways. In addition to improving magnesium bioavailability, citrate itself is a mitochondrial substrate and provides an alkaline load. It chelates dietary oxalates, reducing renal stone formation risk.
• Citrate-malate complexes increase mineral absorption, particularly among individuals with reduced gastric acid secretion
• Malic acid supplies an important substrate in the citric acid cycle, contributing to improved energy metabolism
• Conveniently dosed at 150mg per capsule, allowing for easy therapeutic dosing
Ingredients:Each veg-capsule contains:
Magnesium (citrate, malate) 150mg. (Sourced from 750mg of magnesium complex yielding 150mg elemental magnesium.)
Malic acid, vegetarian capsule (carbohydrate gum [cellulose], purified water, titanium dioxide), microcrystalline cellulose and vegetable grade magnesium stearate (lubricant).
Directions:Adults: Take 3 capsules per day or as directed by a healthcare practitioner.
Cautions:Magnesium supplementation is contraindicated in individuals with impaired kidney function, as well as those with heart blocks, such as atrioventricular or bifascicular blocks. Some people may experience diarrhea. Do not use if safety seal is broken. Keep out of reach of children.