If you experience irritability or insomnia, discontinue use. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle, or are involved in activities requiring mental alertness. If symptoms persist or worsen, consult a health-care practitioner. If you are pregnant or breastfeeding, taking antidepressant medication, hormone replacement therapy (HRT), or birth control pills, consult a health-care practitioner prior to use. Do not use if you have bipolar disorder or bipolar spectrum disorder. Consult a health-care practitioner prior to use if you have epilepsy or if you are taking carbidopa or drugs/supplements with serotonergic activity.
These may include, but are not limited to: L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over-the-counter cough and cold medication containing dextromethorphan, anti-nausea medication, and anti-migraine medication. Discontinue use and consult a health-care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Do not use if you have scleroderma. Some people may experience diarrhea, nausea, vomiting, and abdominal pain. Consumption with alcohol, other medications or natural health products with sedative properties is not recommended.