Bioclinic

Bioclinic Somno-PRO Tropical Breeze, L-Theanine, 5-hydroxytryptophan (5-HTP) and melatonin have all been shown to independently improve sleep quality and quantity, and/or lessen anxiety. L-Theanine is an amino acid found almost exclusively in tea, which influences the central nervous system through a number of mechanisms, primarily by influencing levels of the neurotransmitters dopamine, gamma-aminobutyric acid (GABA), serotonin, norepinephrine, and glutamate. These effects cause a significant increase in alpha brain wave activity, indicative of a state of wakeful relaxation, increased performance under stress, improved learning, and concentration, as well as decreased anxiety.

5-HTP is the intermediary between L-tryptophan and serotonin, a key neurotransmitter associated with sleep, mood and anxiety. 5-HTP bypasses the rate-limiting enzyme tryptophan hydroxylase, which normally limits the conversion of tryptophan to serotonin.

Melatonin is also closely related, and is formed by conversion of serotonin in the pineal gland. Known to regulate many biological rhythms, including the circadian cycle, melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles. Randomized trials have found it to reduce sleep onset latency and improve perceived quality of sleep, without impairing daytime psychomotor performance.

• Reduces anxiety and nervous system excitation, which can inhibit sleep
• Safe without the side effects of prescription or over-the-counter (OTC) medications
• Convenient and fast-acting
• Delicious tropical fruit flavoured chewable
• Addresses every facet of insomnia: difficulty initiating sleep, difficulty maintaining sleep, waking too early in the morning and waking groggy

Each chewable tablet contains:
Medicinal Ingredients:
Suntheanine® l-theanine 100mg, l-5-hydroxytryptophan (5-HTP) (griffonia simplicifolia) (seed) 15mg and melatonin 1.5mg.

Non-Medicinal Ingredients:
Organic cane juice, stearic acid, xylitol, silica, natural flavors (pineapple, banana, pomegranate, mango, passion fruit, peach), citric acid and vegetable grade magnesium stearate (lubricant).

Adults: Chew 2 tablets 30-45 minutes before bedtime or as directed by a healthcare practitioner.

While no specific contraindication exists or is predicted, data is lacking for use during pregnancy, lactation, and in children, and the dosage may need to be reduced for those less than 18. Consult a healthcare practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension or if you have scleroderma. Do not drive or use machinery for 5 hours after taking melatonin. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic Theracurmin, Curcumin's role in the prevention of atherosclerotic plaque formation, platelet aggregation, and LDL oxidation indicates multi-fold cardiovascular benefits, and its ability to inhibit angiogenesis and induce apoptosis in cancer cells suggests both preventative and therapeutic benefit. Prospective clinical trial data has also shown the effectiveness of Theracurmin for knee osteoarthritis symptom relief, and a decreased need for rescue medication.

The limiting factor in curcumin’s efficacy has been its poor systemic bioavailability as it is poorly absorbed in the gastrointestinal tract and rapidly metabolized. Advanced manufacturing techniques used to make Theracurmin have reduced its particle size over 100-fold, and the combined use of natural emulsifiers to form a colloidal suspension has tremendously increased curcumin’s bioavailability. This significantly increases blood levels of curcumin many times that of other preparations, including so-called enhanced forms of curcumin. Theracurmin increases curcumin levels in a linear and dose-dependent manner, bypassing previous limits of curcumin supplementation to achieve unparalleled blood levels of curcumin.

• The highest concentration of Theracurmin curcumin per capsule available
• Smaller capsule, more concentrated potency
• Number one absorbed form of curcumin
• Utilizes patented, natural colloidal dispersion technology to enhance bioavailability and dramatically increase curcumin levels in the blood
• Advanced manufacturing techniques increase free curcumin blood levels in a dose-dependent linear relationship
• Curcumin modulates an impressive number of molecular targets – enhanced absorption allows for significantly greater potency and therapeutic effect
• High potency formula allows for easy dosing
• Suitable for vegetarians/vegans

Each veg-capsule contains:
Medicinal Ingredients:
Theracurmin curcumin from turmeric (Curcuma longa) (rhizome) 120mg.

Non-Medicinal Ingredients:
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, silica, croscarmellose sodium and vegetable grade magnesium stearate (lubricant).

Adults: Take 1 capsule per day or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are pregnant, are taking antiplatelet medication or blood thinners, have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic Calm Pro, L-Theanine is an amino acid found almost exclusively in tea that influences the central nervous system through a number of mechanisms. It crosses the blood-brain barrier in a dose-dependent manner within 30 minutes, and influences levels of the neurotransmitters dopamine, gamma-aminobutyric acid (GABA), serotonin, norepinephrine, and glutamate. These effects cause a significant increase in alpha brain wave activity, indicative of a state of wakeful relaxation, increased performance under stress, improved learning, and concentration, as well as decreased anxiety.

Studies also suggest that L-theanine may have neuroprotective properties against brain injury, such as that resulting from stroke, as well as from environmental neurotoxins. L-Theanine’s neuroprotective capacity has been attributed to its effects on N-methyl-D-aspartate (NMDA) receptors, and brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) production. Because it reduces levels of norepinephrine, it has also been shown to have a hypotensive effect. In clinical trials, L-Theanine has been shown to buffer sympathetic activity during stressful events, reducing subjective as well as physiological stress responses.

• Reduces stress and anxiety, restoring a calm mental state
• Contains Suntheanine, the most clinically studied L-Theanine
• Suntheanine is a pure form of L-Theanine, naturally extracted from green tea using a patented enzymatic process
• Chewable tablets are convenient and fast-acting
• Delicious tropical fruit-flavored chewable
• Suitable for vegetarians/vegans

Each tablet contains:
Medicinal ingredient:
Suntheanine l-theanine 100mg.

Non-Medicinal Ingredients:
Organic cane juice, xylitol, stearic acid, silica, natural fruit flavor (pineapple, banana, pomegranate, mango, passion fruit, orange, tangerine, mandarin), citric acid and vegetable grade magnesium stearate (lubricant).

Adults: Take Chew 2 tablets per day or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic Gaba-Pro, Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system, balancing the excitatory effects of glutamate on neuronal activity. The inhibitory effects of GABA are generally considered to lessen anxiety, relax muscle tension, and have sedative-like effects. In addition, conditions such as anxiety, depression, insomnia, and epilepsy have all been associated with low GABA concentration or activity. GABA has also been shown to cause a significant increase in alpha brain waves compared to control, indicative of a more relaxed state, as well as better concentration. In a clinical trial involving patients with a fear of heights, GABA-Pro was found to increase salivary levels of sIgA while crossing a suspension bridge, as compared to the control group whose salivary IgA levels dropped 35%. This is indicative of the stress-reducing effect of GABA-Pro.

Increasing GABA activity is also a therapeutic target for many medications used in the treatment of insomnia, often by targeting GABA receptors. This has the effect of decreasing waking, shorten sleep latency, and increasing slow-wave sleep.

• Improves calmness and relaxation with daily stress
• Reduces the negative effects of caffeine consumption, and complements other anti-stress supplements
• Fast-acting, effects can be felt in as little as five minutes
• Can last from four to six hours
• Gentle and non-addictive with virtually no side effects
• Delicious tropical fruit-flavored chewable
• Suitable for vegetarians/vegans
• Naturally manufactured via a fermentation process that utilizes Lactobacillus hilgardii, the bacterium used to ferment vegetables in the preparing the traditional Korean dish kimchi

 Each serving (2 chewable tablets) contains:
Medicinal Ingredients:
Gamma-aminobutyric acid (GABA) (from 129mg Pharma GABA 80 Complex) 100mg.

Non-Medicinal Ingredients:
Xylitol, stearic acid, hydroxypropyl cellulose, silica, natural tropical fruit flavor (banana, pomegranate, pineapple, mango, passionfruit, orange, tangerine, mandarin), citric acid and vegetable grade magnesium stearate (lubricant).

Adults: Chew 1–2 tablets 3 times per day or as directed by a health care practitioner. Consult a healthcare practitioner for use beyond 4 weeks.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms persist or worsen. Consumption with alcohol, other medications or health products with sedative properties is not recommended. Keep out of reach of children

Bioclinic Berberine HCL, Traditionally used for gastrointestinal symptoms, berberine has emerged as a potent cardiometabolic aid with diverse benefits and mechanisms of action. It has hypoglycemic effects, via both an inhibition of alpha-glucosidase activity and an upregulation of insulin receptors in peripheral tissues, thereby improving insulin sensitivity.^1,2 Furthermore, it activates Nrf2, a key regulator of cellular antioxidant defense, and attenuates glucose-induced neurotoxicity, suggesting a therapeutic potential for diabetic neuropathy.³

• Hypoglycemic effects via multiple mechanisms, including enhancement of insulin sensitivity
• Favorable effects on blood lipids, including a reduction in triglycerides, and both total and LDL cholesterol
• Activates Nrf-2, a key regulator of antioxidant gene transcription and prevention of glucose-induced neurotoxicity
• Provides 500mg berberine HCl per capsule, the dosing strength used in clinical trials for glucose and lipid control
• Extracted from Berberis vulgaris (European barberry)
• Suitable for vegetarians/vegans

 Each veg-capsule contains:
Medicinal ingredient:
Berberine (Hydrochloride) (Berberis vulgaris) (root) 500mg.

Non-Medicinal Ingredients:
Vegetarian capsule (cellulose, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica and stearic acid.

Adults: Take 1 capsule 2 times per day with meals or as directed by a healthcare practitioner. Consult a health care practitioner for use beyond 3 months.

Consult a health care practitioner if you have leucopenia, a kidney disorder, hypotension or blood pressure problems. Consult a health care practitioner prior to use if you have hypoglycemia or diabetes. Do not use if you are pregnant or breastfeeding. May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain or diarrhea, in which case discontinue use and consult a health care 

Bioclinic Vitamin D3, Vitamin D is a hormone now widely recognized to be important to many-body systems and a large number of physiological processes and it may also be one of the most common nutrient deficiencies in the world. Many recent studies have linked lower levels to an increased risk of cardiovascular disease including hypertension, peripheral vascular disease, coronary artery disease, and heart failure, as well as several types of cancer, autoimmune disease, and type 2 diabetes. Vitamin D is needed for intestinal calcium absorption, skeletal bone integrity as well as skeletal muscle strength and function and has been associated with overall physical fitness. Vitamin D is critical for healthy immune function and may reduce the risk of infection, especially respiratory tract infections. Given that essentially every tissue in the body has a receptor for vitamin D, it is hard to overestimate its importance. Many practitioners recommend supplementation to achieve blood levels of 25-OH-vitamin D between 50-80 nmol/L, which often requires doses of 1000-2000IU per day, and more for those with common genetic variants affecting vitamin D metabolism.

• Vitamin D3 (cholecalciferol) likely more effective at restoring blood levels than D2 form (ergocalciferol)
• In a base of medium-chain triglycerides (MCTs) and organic flaxseed oil for improved intestinal absorption
• MCTs are absorbed directly from the GI tract, thus improving the absorption of vitamin D
• Neutral taste
• Preserved with natural vitamin E
• The liquid form is convenient for a wide range of doses
• 500 drops per bottle
• Suitable for vegetarians

Each drop contains:
Medicinal ingredient:
Vitamin D3 (cholecalciferol) 25mcg (1000IU).

Non-Medicinal Ingredients:
Medium-chain triglycerides, organic flaxseed oil, and natural vitamin E.

Adults: Take 1 serving/drop (0.03ml) per day or as directed by a healthcare practitioner. Shake before use.

Caution is advised for individuals with a hypersensitivity to any of the ingredients, sarcoidosis, lymphoma, tuberculosis, hypercalcemia or renal impairment. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic CereBroVital PQQ-10, PQQ, and CoQ10 are synergistic nutrients that modulate cellular signaling pathways, neutralize reactive oxygen species and support optimal mitochondrial function. Mitochondrial dysfunction plays a role in an ever-increasing range of conditions and is thought to play an important role in age-related decline. CoQ10 is well established as a mitochondrial enhancer, with proven benefit in the treatment and prevention of numerous cardiovascular and neurological conditions. CoQ10 increases the efficiency of mitochondrial ATP production and cellular respiration.

PQQ is a novel biofactor, known to influence multiple cellular pathways, including the production of nerve growth factor (NGF). PQQ has diverse benefits for mitochondrial function and has been shown to attenuate mitochondrial oxidative stress as well as to stimulate mitochondrial biogenesis. It also has neuroprotective properties including protection against glutamate-induced toxicity, a pathway common in many neurodegenerative diseases. BioPQQ is considered a novel cofactor with antioxidant and B vitamin-like activity. It is naturally fermented to enhance absorption.

Taken together, PQQ and CoQ10 have shown clinical benefit for improving cognitive performance such as attention and information processing, and provide superior mitochondrial support.

• Derived from 100% all-natural sourced materials
• BioPQQ is manufactured in Japan using a patented natural fermentation process to enhance absorption
• PQQ has synergistic activity when combined with CoQ10, providing optimal mitochondrial function and energy production

 Each soft gel contains:
Medicinal Ingredients:
Coenzyme Q10 (microorganism) 200mg, PQQ (BioPQQ) pyrroloquinoline quinone disodium salt (providing pyrroloquinoline quinone 17.65mg) 20mg and vitamin E (d-alpha-tocopherol) (sun-E 900) (non-GMO sunflower oil) 5IU (3.35mg AT).

Non-Medicinal Ingredients:
Organic flaxseed oil, soft gel (gelatin, glycerin, purified water, carob), yellow beeswax and non-GMO sunflower lecithin.

Adults: Take 1 soft gel per day or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, taking blood pressure medication, or blood thinners. May cause nausea. Keep out of reach of children.

The majority of the clinical uses for CoQ10 are founded upon its role as an antioxidant,and its role in mitochondrial bioenergetics. It is a coenzyme for numerous reactionsinvolved in cellular respiration, and is required for the efficient formation of adenosinetriphosphate (ATP), the cellular currency which drives the majority of enzymatic reactions. It inhibits peroxidation of cell membrane lipids as well as circulating lipoproteins. CoQ10supports cardiac tissues by improving endothelial function and by having a direct antiatherogeniceffect, which results in lower blood pressure and improved ventricularcontractility.

High dose CoQ10, ranging up to 2,400mg per day, has been used primarily forneurodegenerative diseases such as Parkinson’s and Huntington’s disease, thoughelevated doses have also been used in patients with severe cardiovascular disease oradvanced breast cancer. Clinical trials have shown benefit for a wide range ofcardiovascular conditions, including congestive heart failure, hypertension, and preventionof myocardial infarction. It also had clinical benefits for a number of other conditions,including migraine, periodontal disease, gingivitis, male infertility, and statin-inducedmyopathy.

• Identical to the form produced by the human body for high bioavailability
• Improves many varied health conditions, including cardiovascular disease, cellular decomposition and oxidative stress
• Higher dosage of 400mg reduces the need of taking multiple pills during the day and keeps pace with the research
• Free of contamination by undesirable residue or microorganisms, including bacteria or yeast
• In a base of natural rice bran oil and vitamin E to ensure a stabilized and highly absorbable form of CoQ10

Each softgel contains:
Medicinal ingredient:
Coenzyme Q10 (Microorganism) 400mg.

Non-Medicinal Ingredients:
Rice bran oil, softgel (gelatin, glycerin, purified water, carob) and natural vitamin E.

Adults: Take 1 softgel per day preferably with a meal or as directed by a healthcare practitioner.

While no specific contraindication exists or is predicted, data is lacking for use during pregnancy, lactation and in children, and the dosage may need to be reduced for those less than 18. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic EMIQ, Quercetin, a dietary flavonol known to be one of the most potent plant-derived antioxidants, has multiple biological actions, with anti-inflammatory, anti-thrombotic and vasodilatory benefits in pre-clinical studies. However, clinical trials have not consistently matched expected results based upon pre-clinical studies.

The limiting factor in quercetin’s clinical efficacy appears to be its poor bioavailability. Enzymatically modified isoquercitrin (EMIQ) is a mixture of quercetin mono-glucoside and its alpha-oligo-glucosides that has been shown to have significantly greater bioavailability than other available forms. In animals, EMIQ was shown to produce a 40 fold increase in Cmax (peak plasma concentration) and an 18-fold increase in the area under the curve compared to quercetin. In humans, EMIQ supplementation increased plasma concentrations to a significantly greater degree than other forms, including aglycone and isoquercitrin, with randomized placebo-controlled trials documenting the improvement in allergic symptoms. EMIQ has also shown significantly enhanced biological activity especially in animal models of allergy and neoplasia.

EMIQ has shown significant effects in improving ocular symptoms of hay fever in double-blind clinical studies. In one study, 20 subjects with hay fever due to Japanese cedar pollinosis took two capsules daily of 100mg EMIQ or a placebo for 8 weeks during the pollen season. During the entire study period, the total ocular score and ocular itching score for the EMIQ group were significantly lower than the placebo group. In another study of hay fever due to Japanese cedar pollinosis, 24 subjects took 100mg EMIQ or a placebo for 8 weeks, starting 4 weeks prior to the onset of pollen release. During the entire study period, ocular symptom and medication scores for the EMIQ group was significantly lower than the placebo group. When limited to the pollen release period, ocular symptom and ocular congestion scores for the EMIQ group were significantly lower than the placebo group. Other scores for the EMIQ group, such as ocular itching scores, lacrimation scores, and ocular congestion scores, all tended to be lower.

• 40 times greater absorption than quercetin
• Provides 167mg enzymatically modified isoquercitrin (EMIQ) and 50mg vitamin C per capsule
• Prepared using a natural enzyme process that attaches polysaccharides to convert quercetin into a soluble form
• Capsules suitable for vegetarians/vegans

Each veg-capsule contains:
Medicinal Ingredients:
EMIQ (Enzymatically Modified Isoquercitrin) 167mg and vitamin C (calcium ascorbate) 50mg.

Non-Medicinal Ingredients:
Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water) and vegetable grade magnesium stearate (lubricant).

Adults: Take 1 capsule, 1–2 times per day, or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 8 weeks.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

CortAlign contains a unique variety of botanicals and nutrients shown to have synergistic blunting effect on stress and anxiety, as well as normalizing cortisol secretion. Ashwagandha has a number of adaptogenic effects, including modulating GABA receptors, which is partly responsible for the significant reduction in anxiety and stress as shown in clinical trials. The KSM-66 formulation of Ashwagandha specifically has been shown to reduce serum cortisol levels, and improve markers of depression, stress, and anxiety compared to placebo.

The combination of Magnolia and Phellodendron (Relora Blend) has a synergistic effect for reducing stress and anxiety, and has been shown to reduce salivary cortisol levels and perception of stress, to improve other mood parameters such as depression, and to prevent stress-related weight gain compared to placebo. L-theanine (Suntheanine) has also been shown to reduce anxiety in clinical trials, and to reduce both subjective stress and cortisol production in response to a stressful event. Phosphatidylserine plays a critical role in neuronal cell structure and function, and has been shown to blunt the stress response, improve mood, and normalize cortisol release.

• Promotes relaxation and increases resistance to stress and anxiety
• Provides adaptogenic protection against diverse stressors
• Herbal formula, no glandular extracts
• Each tablet contains clinical dosages of botanicals
• Suitable for vegetarians

Each serving (2 tablets) contains:
Medicinal Ingredients:
KSM-66 ashwagandhatm extract (withania somnifera) (root) (5% withanolides) 300 mg, relora blend 250mg, magnolia bark (magnolia officinalis) (stem bark) (15% honokiol) 68.75mg phellodendron (phellodendron amurense) (stem bark) (05% berberine) 22.50mg, suntheanine l-theanine (camellia sinensis) (leaf)100mg and phosphatidylserine (helianthus annuus) (seed) 25mg.

Non-Medicinal Ingredients:
Microcrystalline cellulose, dibasic calcium phosphate dihydrate, croscarmellose sodium, stearic acid, silica, coating (carbohydrate gum [cellulose], glycerin) and vegetable grade magnesium stearate (lubricant).

Adults: Take 2 tablets per day or as directed by a healthcare practitioner.

Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Consult a healthcare practitioner if you have benign prostate hypertrophy and/or prostate cancer, are taking any prescription medication, have a kidney disorder, or if you have blood pressure problems. Consult a healthcare practitioner prior to use if you suffer from any psychological disorder and/or condition such as frequent anxiety or depression. May cause heartburn, shaking hands, perilabial numbness, sexual dysfunction and thyroid dysfunction. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Do not use if you are pregnant or breastfeeding. Keep out of reach of children.

Bioclinic Melatonin Time Release,  Melatonin plays a major role in the circadian regulation of the sleep-wake cycle and has proven critically important for both initiation and quality of sleep, with supplementation improving sleep in healthy individuals and in those with insomnia, as well as preventing phase shifts due to jet lag or rotating work schedules. Time release melatonin improves not only the initiation of sleep, but its longer plasma half-life helps to maintain and improve the quality of sleep.

Melatonin is particularly effective in older individuals, regardless of endogenous melatonin levels, in both the short and long term, with improvements in sleep quality, morning alertness, sleep onset latency and quality of life, with no relevant adverse effects or dependency. It has been shown to improve sleep quality in children with diverse sleep complaints, including delayed sleep phase syndrome and impaired sleep maintenance, or other sleep-related disorders. Melatonin has diverse physiological benefits, including improved bone mineral density in those with osteopenia, reduced depressive symptoms in women undergoing breast cancer surgery, and lowered hepatic enzymes in those with non-alcoholic steatohepatitis. Time-release melatonin has had clinical improvements in mood in those with sleep disturbances, as well as cognitive performance in those with Alzheimer’s disease.

• Clinically shown to improve sleep quality, morning alertness, sleep onset latency and quality of life, with no adverse effects of dependency
• Supplementation linked to improved mood and cognitive function among those with impaired sleep
• Provides 5mg time-released melatonin per tablet
• Time-release formulation sustains plasma levels for a longer period, enhancing sleep initiation, maintenance, and quality
• Suitable for vegetarians/vegans

Each tablet contains:
Medicinal ingredient:
Melatonin (non-animal source) 5mg. 

Non-Medicinal Ingredients:
Dibasic calcium phosphate dihydrate, microcrystalline cellulose, carbohydrate gum [cellulose] and vegetable grade magnesium stearate (lubricant).

Adults: Take 1-2 tablets per day at or before bedtime, or as directed by a healthcare practitioner. Jet Lag: Take once a day at bedtime after darkness has fallen, while traveling, and at destination until adaptation to the new daily pattern. For occasional short-term use. Do not drive or use machinery for 5 hours after taking melatonin. For use beyond 4 weeks, consult a healthcare practitioner.

Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. If you are taking one of the following medications, consult a healthcare practitioner prior to use: anticoagulant, anticonvulsant, blood pressure medications, immunosuppressive medications, sedative, hypnotic or psychotropic medications, or steroids. If you have one of the following conditions, consult a healthcare practitioner prior to use: asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorders. If symptoms persist continuously for more than 4 weeks (chronic insomnia) consult a healthcare practitioner. Mild gastrointestinal symptoms (such as nausea, vomiting, or cramping) have been known to occur, in which case discontinue use. Rare allergic reactions have been known to occur, in which case discontinue use. Do not use if you are pregnant or breastfeeding. Keep out of reach of children. Do not use if safety seal is broken.

Phosphatidylserine is the most abundant phospholipid in the brain. Along with other phospholipids, phosphatidylserine plays important roles in the structure and fluidity of cell membranes, intercellular communication and protection of cells from damage produced by free radicals. Due to its presence in the brain, the effects of phosphatidylserine on the central nervous system have been widely studied. Importantly, clinical studies suggest phosphatidylserine supports cognitive functions which tend to decline with age such as memory, learning, concentration and vocabulary. In addition to this role in age-related cognitive decline, phosphatidylserine has been used in Alzheimer’s disease,1 attention deficit-hyperactivity disorder (ADHD), depression and improving mental function in young people. In a double-blind placebo-controlled trial, the combination of phosphatidylserine with DHA showed improvement in cognitive performance in non-demented elderly with memory complaints. Specifically, verbal immediate recall was significantly improved in the treatment group, and post-hoc analysis revealed that a subset of participants with relatively good cognitive performance at baseline had significant treatment-associated improvements in immediate and delayed verbal recall, learning abilities and time to copy complex figure. In the past, commercial sources of phosphatidylserine have been derived from animal sources. However, enhanced technology has enabled the development of a plant-based source of this important nutrient. Phosphatidylserine by Bioclinic Naturals is made from Sharp-PS Green, which is derived from non-GMO sunflower oil and is 100% soy free.

• Provides 100mg phophatidylserine, allowing for easy and clinically relevant dosing
• Lipid base provides superior bioavailability
• Non-GMO, 100% soy-free, and animal-free source (derived from sunflower oil)
• Contains naturally occurring phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), all of which contribute to cellular and lipid bilayer function

Each veg-capsule contains:
Medicinal Ingredients:
Phosphatidylserine (Helianthus annuus) (seed) (From 565mg non-GMO sunflower lecithin complex) 100mg.
*Contains naturally occurring phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE).

Non-Medicinal Ingredients:
Softgel (gelatin, glycerin, purified water) and non-GMO sunflower oil.

Adults: Take 1 softgel 3 times per day or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

L-glutamine is the most plentiful amino acid in the body, a Krebs cycle intermediary of particular importance to intestinal and immune cells, and one known to be depleted following strenuous physical activity. L-glutamine supplementation has been shown to prevent an exercise-induced increase in intestinal permeability, by promoting tight junction stability, upregulating anti-inflammatory cytokine production, and suppressing inflammation, notably NF-κB activation. L-glutamine also stimulates protein synthesis pathways, while inhibiting protein degradation.

Curcumin has well-established anti-inflammatory effects with multiple molecular targets, including NF-κB, as well as cyclooxygenases and lipoxygenases. Curcumin supplementation has been shown to mitigate damage to muscles following exercise, reduce pain due to delayed onset muscle soreness, and enhance the recovery of muscle performance. Theracurmin specifically has been shown to prevent both an increase in creatine kinase and muscle degradation following eccentric exercise. Theracurmin has been proven effective for symptom relief and a reduced need for rescue medication among participants with knee osteoarthritis in a prospective clinical trial. L-glutamine and Theracurmin combined target multiple mechanisms associated with muscle repair and function.

• Provides 5g L-glutamine and 30mg Theracurmin per serving
• Targets multiple pathways of inflammation and protein synthesis to improve muscle repair and recovery following exercise
• Provides immune and digestive system support
• Theracurmin has higher bioavailability compared to standard curcumin in humans
• Powder formulation allows for flexible and convenient dosing
• Suitable for vegetarians/vegans

Each serving (5.2g) contains:
Medicinal Ingredients:
Micronized l-glutamine 5g and theracurmin curcumin from turmeric (curcuma longa) (rhizome) 30mg.

Non-Medicinal Ingredients:
Maltose, gum ghatti, dextrin and citric acid.

Adults: Take 1 serving (5.2g) per day or as directed by a healthcare practitioner. Mix product well in 375–500ml of liquid (water, juice, etc.) immediately before consumption.

Ensure to drink enough fluid before, during, and after exercise. Consult a healthcare practitioner if you are following a low protein diet. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, taking antiplatelet medication or blood thinners, have gallstones or a bile duct obstruction, or have stomach ulcers or excess stomach acid. Keep out of reach of children.

IB Care contains enterically coated peppermint, oregano, and caraway oils, all shown to have benefit for diverse gastrointestinal disturbances. Peppermint oil is known to influence gastric motility, accelerating early gastric emptying with an antispasmodic effect on the stomach. It also increases the relaxation time of the pyloric valve, decreases the resting pressure of the lower esophageal sphincter, and has synergistic benefit when combined with caraway oil, producing smooth muscle relaxation in the stomach and duodenum. Oregano oil has demonstrated antimicrobial effects against H. pylori, the primary cause of peptic ulcer disease and dyspepsia, as well as other GI pathogens.

Clinically, enterically coated preparations of these oils have demonstrated benefits in a number of clinical trials. Improvement has been shown for dyspepsia and symptoms such as pain, heaviness, and abdominal pressure in controlled trials, regardless of H. pylori status and even in those with significant epigastric pain. Additionally, enteric coated peppermint oil demonstrated clinical efficacy in a number of trials for irritable bowel syndrome, showing improvement in the majority of participants, and in both children and adults.

• Provides clinically effective amounts of peppermint, caraway, and oregano oils at proven dosages
• Potent amounts of active components: 50% menthol (peppermint), 60% phenol (oregano), and 50% carvone (caraway)
• Enteric coating improves efficacy, allowing for antispasmodic effect in gastric and upper intestinal tissues
• Research confirms that peppermint oil is more effective and better tolerated when protected from stomach acid
• Enteric coating also reduces adverse effects and peppermint taste

Each softgel contains:
Medicinal Ingredients:
Peppermint oil (mentha x piperita) (aerial) (50% menthol 50mg) 100mg (110mcl), oregano oil (thymus capitatus) (aerial) (60% carvacrol) (60% phenol 42mg) 70mg and caraway oil (carum carvi) (seed) (50% carvone 15mg) 30mg (33.3mcl).

Non-Medicinal Ingredients:
Softgel (gelatin, glycerin, purified water) and enteric coating (purified water, ethylcellulose, medium chain triglycerides, oleic acid, sodium alginate, stearic acid).

Adults: Take 1 enteric coated softgel, 3 times per day, 15-30 minutes before a meal, or as directed by a healthcare practitioner. Take a few hours before or after taking supplements containing iron, zinc, calcium or copper. Use in 3-week cycles, with an interruption of at least one week between the cycles.

Do not use if you are pregnant or breastfeeding or if you have hypersensitivity or are allergic to herbs in the Lamiaceae/Apiaceae/Carrot family. Consult a healthcare practitioner if symptoms persist or worsen. Consult a healthcare practitioner prior to use if you have gallstones, anemia, hiatus hernia, gastroesophageal reflux or if you are experiencing acute abdominal pain. Hypersensitivity has been known to occur, in which case discontinue use. Discontinue use if you experience gastrointestinal upset. Keep out of reach of children.

Allergic rhinitis is a common upper respiratory problem seen routinely in clinical practice. This problem occurs when inhaled allergens come in contact with IgE antibodies on the surface of the airway triggering numerous acute symptoms: nasal congestion, sneezing, a watery ocular discharge, rhinnorea, and a pruritic palate along with sinus and eustachian tube congestion. According to the Centers for Disease Control (CDC) in the United States, 17.9 million adults and 7.1 million children were diagnosed with hay fever in the year 2010. While numerous prescription and over the counter (OTC) antihistamines can benefit by relieving symptoms, they are often fraught with side effects including dry mouth, sleepiness, and restlessness. Allerieva represents an alternative that is safe for both short and long term use. A recent controlled study concluded that 2000mg per day of the blue green algae spirulina significantly reduced the symptoms of allergic rhinitis including nasal discharge, sneezing, nasal congestion, and itching after three weeks of use. In humans, spirulina acts on hay fever symptoms by significantly reducing the secretion of an inflammatory cytokine IL-4 by 32%.

• Vitamin C has been shown to decrease blood histamine levels
• Vitamin C also raises glutathione levels by 50%. Increasing this potent antioxidant may help reduce nasal obstruction, rhinorrhea and ear fullness.
• EMIQ (enzymatically modified isoquercitrin) has been shown to reduce ocular allergic symptoms in those with pollinosis
• The patented bioflavonoid pycnogenol, when given 5 weeks before birch allergy season, reduced eye and nasal symptoms by 35% and 19.5% respectively
• Stinging nettle leaf has been shown in vitro to inhibit the pro-inflammatory pathways related to allergic rhinitis
• Suitable for vegetarians/vegans

Each veg-capsule contains:
Medicinal Ingredients:
Organic spirulina (spirulina platensis) (whole) 335mg, vitamin C (calcium ascorbate) 175mg, stinging nettle 4:1 extract (urtica dioica) (leaf) 50mg, pycnogenol (french maritime pine bark extract) (pinus pinaster) (bark) (65-75% procyanidins) 17mg and EMIQ (enzymatically modified isoquercitrin) (providing 15 mg of highly absorbable quercetin) 50mg .

Non-Medicinal Ingredients:
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, silica and vegetable grade magnesium stearate (lubricant).

Adults: Take 2 capsules 3 times per day or as directed by a healthcare practitioner. If used as a diuretic, for occasional use only.

Do not use if you are pregnant or breastfeeding or have any known allergy to any of the ingredients in this product. Consult a healthcare practitioner if symptoms persist or worsen. Stop this product 1 week prior to surgery. Keep out of reach of children.

Bioclinic NAC, N-Acetyl-L-Cysteine (NAC) is known to have diverse physiological and therapeutic benefits, attributed largely to its antioxidant, anti-inflammatory and mucolytic effects. It is well-accepted to increase the critical intracellular antioxidant glutathione, by supplying a stable form of L-cysteine, the rate-limiting factor for glutathione synthesis. The number of conditions with altered glutathione homeostasis continues to grow, including not only cardiovascular, neurodegenerative, pulmonary and age-related diseases, but there is also a growing clinical recognition of metabolic disturbances linked to environmental toxin exposure, such as diabetes and persistent organic pollutants. By restoring glutathione levels, NAC also is well established as the most effective therapy for acetaminophen toxicity.

Additionally, NAC’s ability to cleave disulfide bonds provides efficacy as a mucolytic agent, with clinical benefit for individuals with COPD and pulmonary fibrosis. Breaking disulfide bonds may also be the same mechanism by which it lowers homocysteine and improves endothelial function in coronary artery disease. NAC has immunomodulating and anti-inflammatory effects, improving influenza symptomology and SLE disease activity. By modulating glutamatergic and neurotropic pathways, NAC also has shown benefits for schizophrenia, bipolar disorder, and autism.

• Supports glutathione synthesis, key cellular antioxidant, and conjugator of numerous environmental toxins
• Improves endothelial function and supports nitric oxide synthesis
• 500mg NAC per capsule allows for easy and therapeutic dosing levels
• Stable and well-absorbed form of the easily oxidized amino acid L-cysteine
• The evidence base for diverse clinical uses

Each veg-capsule contains:
Medicinal Ingredients:
NAC (N-Acetyl-L-Cysteine) (Free Form) 500mg.

Non-Medicinal Ingredients:
Rice starch, vegetarian capsule (carbohydrate gum [cellulose], purified water) and vegetable grade magnesium stearate (lubricant).

Adults: Take 1 capsule 2–3 times per day or as directed by a healthcare practitioner. Do not use beyond 24 weeks. Take with meals providing protein.

Consult a healthcare practitioner prior to use if you are taking nitroglycerin. Do not use if you have acetylcysteine allergy, or if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you are taking antibiotics. Consult a healthcare practitioner if you have cystinuria. Keep out of reach of children.

Active B Complex provides the most biologically active forms and clinically relevant doses of a unique B vitamin combination. Quatrefolic folate provides (6S)-5-Methyltetrahydrofolate acid (MTHF), the active form of folate at the cellular level, the form found in circulation, and the only form able to cross the blood brain barrier. This form of folate bypasses enzymatic conversion by methylene tetrahydrofolate reductase (MTHFR), an enzyme with common genetic polymorphisms known to impair activity. Quatrefolic acid administration has been associated with higher peak (6S)-5-MTHF levels than both folic acid and calcium 5-MTHF, with higher plasma folate levels even in those with high functioning MTHFR polymorphisms.

In addition to superior folate bioavailability, Active B Complex contains superior forms of each B vitamin. Benfotiamine is a lipid soluble form of vitamin B1 with higher bioavailability than thiamine, used in the treatment of diabetic neuropathy because it blocks several hyperglycemic pathways and prevents endothelial dysfunction. Riboflavin 5’-phospate and pyridoxal 5’-phosphate (PLP) are biologically active forms of B2 and B6 – PLP being the most important member of the B6 group, and is the active coenzyme for more than 100 enzymes, bypassing hepatic conversion to an active form.

• Provides the natural and most bioactive form of folate, Quatrefolic folate (6S)-5-MTHF, with no synthetic or racemic components
• Quatrefolic folate supplementation has a greater increase in plasma folate compared to folic acid and calcium 5-MTHF
• Contains most bioactive and bioavailable forms of each B vitamin, including methylcobalamin (B12), riboflavin 5’-phosphate (B2), and pyridoxal 5’-phosphate (B6)
• Broad spectrum B complex, with inositol, biotin, and choline
• Suitable for vegetarians/vegans

Each veg-capsule contains:
Medicinal Ingredients:
Vitamin B1 (thiamine hydrochloride) 25mg, benfotiamine 10mg, vitamin B2 (riboflavin 5’-phosphate sodium) 10mg, niacin (inositol hexanicotinate) 100mg, pantothenic acid (calcium d-pantothenate) 100mg, vitamin b6 (pyridoxal 5-phosphate) 25mg, vitamin B12 (methylcobalamin) 500mcg, folate (from (6s)-5-methyltetrahydrofolic acid (mthf), glucosamine salt, quatrefolic) 400mcg, biotin 250mcg, choline (citrate) 50mg and inositol (inositol, inositol hexanicotinate) 50mg.

Non-Medicinal Ingredients:
Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant) and silica.

Take 1 capsule per day with food or as directed by a healthcare practitioner.

No reports exist for neuropathies associated with pyridoxal 5’-phosphate, though doses of pyridoxine at 1-3g per day have been associated with peripheral neuropathy when used in isolation. People sensitive to nicotinic acid may experience flushing of the skin that is generally mild and transient. Keep out of reach of children. Do not use if safety seal is broken.

Bioclinic Sereni-PRO,  Ashwagandha (Withania somnifera), Siberian ginseng (Eleutherococcus senticosus), lavender (Lavandula angustifolia), and Rhodiola (Rhodiola Rosea) are herbs known for their adaptogenic and calming properties, and that mediate the effects of stress and fatigue. Adaptogens induce stress-protective benefits, mediated through regulation of homeostasis via several mechanisms of action associated with the hypothalamic-pituitary-adrenal axis. Ashwagandha has been found to limit the production of dopamine and other hormones in response to stress and acts as a GABA receptor agonist, all of which have the effect of reducing the overall stress response. Siberian ginseng root contains eleutherosides known to have anti-fatigue and anti-stress effects, as well as immunomodulatory effects, and has been shown clinically to have therapeutic efficacy for chronic fatigue, stress, and improve athletic performance. Lavender oil is thought to act on both the central and sympathetic nervous system and clinically has been shown to have a calming and relaxing effect, promoting an improved sense of wellbeing. Rhodiola Rosea has been clinically shown to improve attention, cognitive function and mental performance, decrease the cortisol response to stress, and to exert an anti-fatigue effect.

• Anti-stress and antioxidant adaptogens restore and revitalize the body’s glands and organs under isolated and chronic stress conditions
• The herbal formula that contains no glandular extracts
• Provides broad-spectrum help for a variety of stress-related disorders
• Safe, non-addictive, and may be used long term
• Suitable for vegetarians/vegans

Each veg-capsule contains:
Medicinal Ingredients:
Sensoril ashwagandha extract (Withania somnifera) (root and leaf) (standardized to 8% withanolides) 125mg, Siberian ginseng extract (Eleutherococcus senticosus) (root) (standardized to 0.8% eleutherosides) 75mg, lavender 5:1 extract (Lavandula angustifolia) (aerial) 75mg and rhodiola extract (Rhodiola Rosea) (root) (standardized to 3.5% rosavins, 1% salidroside) 37.5mg.

Non-Medicinal Ingredients:
Rice starch, vegetarian capsule (carbohydrate gum [cellulose], purified water) and vegetable grade magnesium stearate (lubricant).

Adults: Take 1-2 capsules 2 times per day or as directed by a healthcare practitioner. Not to be taken immediately before bedtime. Consult a healthcare practitioner for use beyond 1 month.

Consult a healthcare practitioner prior to use if you have any type of acute infection or if you are pregnant or breastfeeding. Consult a healthcare practitioner if symptoms persist or worsen. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Do not use if you have high blood pressure. Do not use if safety seal is broken. Keep out of reach of children.

L-Theanine, 5-hydroxytryptophan (5-HTP) and melatonin have all been shown to independently improve sleep quality and quantity, and/or lessen anxiety. L-Theanine is an amino acid found almost exclusively in tea, which influences the central nervous system through a number of mechanisms, primarily by influencing levels of the neurotransmitters dopamine, gamma-aminobutyric acid (GABA), serotonin, norepinephrine and glutamate. These effects cause a significant increase in alpha brain wave activity, indicative of a state of wakeful relaxation, increased performance under stress, improved learning and concentration, as well as decreased anxiety.

5-HTP is the intermediary between L-tryptophan and serotonin, a key neurotransmitter associated with sleep, mood, and anxiety. 5-HTP bypasses the rate limiting enzyme tryptophan hydroxylase, which normally limits the conversion of tryptophan to serotonin.

Melatonin is also closely related, and is formed by conversion of serotonin in the pineal gland. Known to regulate many biological rhythms, including the circadian cycle, melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles. Randomized trials have found it to reduce sleep onset latency and improve perceived quality of sleep, without impairing daytime psychomotor performance.

• Reduces anxiety and nervous system excitation, which can inhibit sleep
• Safe, without the side effects of prescription or over-the-counter (OTC) medications
• Enteric coated to reduce the risk of nausea
• Addresses every facet of insomnia: difficulty initiating sleep, difficulty maintaining sleep, waking too early in the morning, and waking groggy

Each softgel contains:
Medicinal Ingredients:
Suntheanine l-theanine 100mg, 5-hydroxy-l-tryptophan (L-5-HTP) (griffonia simplicifolia) (seed) 15mg and melatonin 1.5mg.

Non-Medicinal Ingredients:
Softgel (gelatin, glycerin, purified water), organic flaxseed oil, yellow beeswax, non-GMO sunflower lecithin and enteric coating (purified water, ethylcellulose, medium chain triglycerides, oleic acid, sodium alginate, stearic acid).

Adults: Take 2 softgels per day 30-45 minutes prior to bedtime or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 4 weeks. Do not take on an empty stomach.

Consult a health care practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension. Consult a health care practitioner prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include but are not limited to L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over-the-counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia), or if symptoms persist or worsen. Some people may experience diarrhea, nausea, vomiting and abdominal pain. Discontinue use if you show signs of weakness, oral ulcers, skin changes or abdominal pain accompanied by severe muscle pain. Do not use if you are taking blood pressure, immunosuppressive or sedative/hypnotic medication or if you are pregnant or breastfeeding or have scleroderma. Some people may experience drowsiness. Exercise caution if you are involved in activities requiring mental alertness. Do not drive or use machinery for 5 hours after taking this product. Keep out of reach of children.

Bioclinic 5-HTP, 5-Hydroxytryptophan (5-HTP) is an amino acid that is the middle step between tryptophan and the neurotransmitter serotonin. Scientific evidence indicates that low serotonin levels are linked to a number of common conditions, including depression, obesity, headache/migraine, and fibromyalgia. 5-HTP boosts serotonin levels and may offer a benefit in conditions linked to low serotonin levels.

5-HTP may help patients unresponsive to standard antidepressant drugs and some evidence suggests it may be comparable, if not superior, to conventional antidepressants, with fewer side effects. Taking 5-HTP can also aid pain syndromes such as migraine and fibromyalgia. It is thought both conditions reflect a serotonergic defect. Fibromyalgia suffers have experienced improved symptoms including pain severity, morning stiffness, and sleeplessness with 5-HTP supplementation. 5-HTP is known to increase sleep quality, which is critical in those patients suffering from depression or fibromyalgia. In fact, 5-HTP is known to promote and maintain sleep in normal subjects, as well as those experiencing insomnia.

Research has indicated that 5-HTP may aid weight loss. Early animal studies indicated that genetically obese rats had decreased activity of the enzyme that converts tryptophan to 5-HTP and subsequently serotonin, allowing them to overeat. The same mechanism exists in genetically predisposed humans. By providing preformed 5-HTP, this genetic defect is bypassed and more serotonin is manufactured. Human clinical trials have corroborated that 5-HTP is able to reduce caloric intake, promote satiety and induce weight loss without a conscious effort by subjects to lose weight.

• Naturally sourced from the seed of African plant Griffonia simplicifolia
• Enteric-coated to reduce the likelihood of nausea
• Unlike L-tryptophan, 5-HTP readily crosses the blood-brain barrier increasing central nervous system synthesis of serotonin

Each caplet contains:
Medicinal ingredient:
L-5-Hydroxytryptophan (Griffonia simplicifolia) (seed) 100mg.

Non-Medicinal Ingredients:
Dibasic calcium phosphate dihydrate, purified water, microcrystalline cellulose, enteric coating (purified water, ethylcellulose, medium-chain triglycerides, oleic acid, carbohydrate gum [cellulose], glycerin, sodium alginate, stearic acid) and vegetable grade magnesium stearate (lubricant).

Healthy Mood Balance: Take 1 caplet 3 times per day with food or as directed by a healthcare practitioner. To minimize the risk of gastrointestinal side effects, slowly increase the dose over a period of 2 weeks. Use for a minimum of 1 week to see beneficial effects. Consult a health care practitioner for use beyond 1 year.

Sleep Aid: Take 1 caplet 1–2 times per day with food 30–45 minutes prior to bedtime, or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or are involved in activities requiring mental alertness. Some people may experience diarrhea, nausea, vomiting and abdominal pain. Discontinue use and consult a healthcare practitioner if you show signs of weakness, oral ulcers or abdominal pain accompanied by severe muscle pain, or if you experience skin changes, or if symptoms persist or worsen. Consult a healthcare practitioner if sleeplessness persists for more than 3 weeks, or if you are pregnant or breastfeeding. Keep out of reach of children.

Digest-ProGD HP is a high potency proprietary enzyme blend, providing fungal proteases derived from Aspergillus oryzae, bacterial protease derived from Bacillus subtilis, as well as comprehensive carbohydrate digestive support from papain, bromelain, and fungal digestive enzymes. Aspergillus oryzae extracts are rich in prolyl endopeptidases as well as dipeptidyl peptidase IV (DPP-IV) – a multifunctional serine protease which targets proline containing peptides, such as those found in both gliadin and casein, both proteolytically resistant proteins.

• Provides fungal and bacterial proteases to hydrolyze difficult-to digest proline-containing peptides such as gluten and casein
• Provides wide spectrum carbohydrate digestion with plant-based papain, bromelain, and fungal digestive enzymes
• High potency formulation allows for easy dosing, with nearly 300 mg enzyme blend delivered in each vegetarian capsule
• Completely suitable for vegetarians and vegans

Each veg-capsule contains:
Medicinal Ingredients:
Proprietary enzyme blend 295mg, fungal protease (aspergillus flavus var. oryzae) (whole) 153.35mg (690 FCC SAP), bacterial protease (bacillus subtilis) (whole) 75mg (75,000 FCC PC), fungal protease (aspergillus flavus var. oryzae) (whole) 24.36mg (6,700 FCC HUT), alpha-amylase (aspergillus flavus var. oryzae) (whole) 18.67mg (2,800 FCC DU), bromelain (ananas comosus var. comosus) (stem) 9.55mg (315,000 FCC PU), papain (carica papaya) (fruit) 7.5mg (315,000 FCC PU), cellulase (trichoderma longibrachiatum) (whole) 3.78mg (680 FCC CU) and hemicellulase (aspergillus niger) (whole) 2.34mg (1,875 FCC HCU).

Non-Medicinal Ingredients:
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose and vegetable grade magnesium stearate (lubricant).

Adults: Take 1 capsule 3 times per day with meals or as directed by a healthcare practitioner. Consult a healthcare practitioner for prolonged use.

Consult a health care practitioner prior to use if you have diabetes, a gastrointestinal lesion, ulcer, are taking an anticoagulant, blood thinner, anti-inflammatory, antibiotic, or are having surgery, are pregnant or breastfeeding, or have allergy to latex or fruits (avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, tomato). Do not use if safety seal is broken.

The only lipid-soluble endogenously synthesized antioxidant, CoQ10 (ubiquinone) has well established roles as a free radical scavenger in both mitochondrial and lipid membranes, as an electron carrier essential to cellular respiration and ATP production and recently has it has been shown to influence gene expression.

Given the central role of CoQ10 in mitochondrial function and cellular antioxidant protection, its clinical applications are extensive. Just a few of the many health conditions associated with requiring supplemental CoQ10 to boost levels are: general antioxidant support, cardiovascular disease (high blood pressure, congestive heart failure, cardiomyopathy, protection during cardiac surgery, high cholesterol being treated by drugs, especially statins), cancer (to boost immune function and/or offset chemotherapy side effects), diabetes mellitus, male infertility, Alzheimer’s (prevention) and Parkinson’s disease (prevention and treatment), periodontal disease and macular degeneration. The reduced form of CoQ10, ubiquinol, has emerged as a more effective therapy for increasing plasma levels of CoQ10 than most forms of ubiquinone due to its increased solubility.

• Increases plasma levels of CoQ10 significantly more per mg compared to ubiquinone
• Allows for higher peak plasma levels of CoQ10 especially when higher plasma CoQ10 are required
• Ubiquinol is a highly absorbable and bioavailable form of CoQ10
• Kaneka QH brand ubiquinol is naturally produced via yeast fermentation and is free of the impurities of synthetically processed CoQ10
• Genetically modified organism (GMO) free, allergen free and Kosher certified

Each softgel contains:
Medicinal Ingredients:
Ubiquinol CoQ10 (kaneka Q+) (microorganism) 100mg and organic flaxseed oil (linum usitatissimum) (seed) 297mg.

Non-Medicinal Ingredients:
Softgel (gelatin, glycerin, purified water, carob), yellow beeswax, non-GMO sunflower lecithin and vitamin E (non-GMO sunflower oil).

Adults: Take 1 softgel 1-3 times per day or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are taking blood pressure medication or blood thinners, or if you are pregnant or breastfeeding. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic Thyrovantage HT, Subclinical hypothyroidism (SHT) has been reported to present in 4 to 20% of the adult population. Patients with this thyroid disorder typically present with a serum TSH that can range from 5 to 9 mU/L along with varying degrees of symptomatology including bradycardia, constipation, dry skin, hoarseness, fatigue, and muscle cramps. In addition, untreated SHT may have significant health consequences as it increases the risk of coronary heart disease (dyslipidemia, endothelial vascular dysfunction) in adults. While there are a number of prescriptive treatment options including low doses of L-thyroxine or whole gland thyroid, both nutritional and herbal remedies are useful therapeutic adjuncts. The amino acid L-tyrosine, as found in ThyroVantage HT, is an important nutritional precursor for thyroxine (T4). Biochemically, L-tyrosine is iodinated from thyroglobulin to form diiodotyrosine which in turn is oxidized to the hormone thyroxine (T4). Iodide is another important factor in thyroid function with the oral administration of 500 mcg per day resulting in a significant increase in TRH-stimulated serum TSH concentrations.

• Z guggulsterone from Commiphora Mukul stimulates thyroid function in vivo
• Withania somnifera promotes T4 function in vivo
• Added pantothenic acid to help support adrenal gland responsiveness
• In vivo manganese supports the creation of triiodothyronine (T3)
• Copper is linked to decreased plasma T3 concentrations in animals and humans
• Suitable for vegetarians

Each veg-capsule contains:
Medicinal Ingredients:
L-tyrosine 250mg, ashwagandha extract (Withania somnifera) (root) (1.5% withanolides) 75mg, guggul extract (Commiphora Mukul) (gum oleoresin) (2.5% guggulsterone) 60mg, d-pantothenic acid (calcium d-pantothenate) 50mg, copper (cupric gluconate) 250mcg, manganese (citrate) 250mcg, iodine (potassium iodide) 50mcg and selenium (selenomethionine) 25mcg.

Non-Medicinal Ingredients:
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant).

Adults: Take 2-4 capsules per day, 1-2 capsules with breakfast and 1-2 capsules with lunch, or as directed by a healthcare practitioner.

For adult use only. Consult a healthcare practitioner prior to use if you are following a low protein diet. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Do not use if you are pregnant or breastfeeding. Do not use if safety seal is broken. Keep out of reach of children.

Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA, as well as the conversion of homocysteine to methionine by methionine synthase, which is then converted into S-adenosylmethionine. A B12 deficiency causes impairments in both of these pathways, disrupting neurological function, including poor formation of myelin nerve sheaths, production of toxic levels of homocysteine, and inefficient energy production in all cells.

Because of its relationship to myelin production and neurological function, high dose B12 has been used in a variety of neurodegenerative diseases, including Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis.

Some individuals, especially those with malabsorption or low dietary intake, are at higher risks for a B12 deficiency. Individuals with impaired absorption of B12 rely on passive absorption, which is typically 1% of the ingested amount. Thus high doses are required for those with greater B12 needs, such as elderly individuals and those with neurodegenerative disorders.

• Lowers homocysteine levels for protective cardiovascular benefits
• Methylcobalamin is the active form of vitamin B12 for maximum benefit
• Superior to the more common form, cyanocobalamin, which does not convert to enough methylcobalamin to correct some forms of anemia, neurological defects, and aging
• Sublingual tablets allow for fast acting delivery system directly into blood stream
• Suitable for vegetarians

Each tablet contains:
Medicinal ingredient:
Vitamin B12 (methylcobalamin) 5000mcg.

Non-Medicinal Ingredients:
Lactose, microcrystalline cellulose, croscarmellose sodium and vegetable grade magnesium stearate (lubricant).

Adults: Take 1 tablet per day or as directed by a health care practitioner. Dissolve under the tongue. Consult a healthcare practitioner for use beyond 4 months.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. Do not use if safety seal is broken. Keep out of reach of children.

Bone Assist provides clinically relevant doses of the three fat-soluble vitamins essential to optimal bone health. Although needed for cardiovascular health, blood sugar regulation, immune function, and inflammation control, vitamins A, D, and K2 have complementary physiological bone-related functions, such as modulating gene expression in osteoblasts and carboxylating osteocalcin, an enzyme needed for bone formation. This is exemplified by a reduction in undercarboxylated osteocalcin and an increase in bone mineral density (BMD) in postmenopausal women when vitamin K is added to vitamin D supplementation.

Vitamin D has diverse and significant functions in multiple body systems, and widespread deficiency magnifies these crucial roles. Supplementation is associated with a well-established reduction in osteoporotic fracture. Correcting a vitamin D deficiency is critical when supplementing with vitamin A, as vitamin A appears to promote bone health if vitamin D levels are adequate.6 Vitamin K is now recognized as being necessary not only for coagulation, but for the carboxylation of enzymes critical for both bone and blood vessel health. Indeed, meta-analysis has shown improvement in vertebral BMD and reduction in fracture among post-menopausal women with osteoporosis, while controlled trial data shows a reduction in the age-related decline in BMD among healthy postmenopausal women. The naturally derived MK-7 form in Bone Assist has a longer half-life than any other form.

• Potent physiological balance of key fat-soluble vitamins, A, D, and K, critical to bone health
• Contains vitamin K2 (MK-7), the most bioactive and long-lasting form
• MK-7 shown to increases vertebral BMD among postmenopausal women
• Provides vitamin D3, shown to be more effective than D2 in maintaining blood levels of 25-OH vitamin D
• Optimal form of vitamin A, palmitate, bypasses impaired conversion of carotenoids (affects nearly half the population)
• Suitable for vegetarians

Each serving (0.25ml)contains:
Medicinal Ingredients:
Vitamin A (palmitate) 500IU (151mcg RAE), vitamin D3 (cholecalciferol) 1000IU (25mcg) and vitamin K2 (menaquinone) (MK-7) (natto bean) 50mcg.

Non-Medicinal Ingredients:
Medium chain triglycerides, organic flaxseed oil, natural vitamin E (non-GMO sunflower oil) and natural vanilla flavour.

Take 1 serving (0.25ml) per day or as directed by a healthcare practitioner.

Consult a healthcare practitioner prior to use if you are taking blood thinners. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

As the second most abundant intracellular action and a cofactor for at least 300 metabolic reactions, magnesium is a critical regulator of numerous cellular functions, ion channels, signalling pathways, enzymes, and metabolic pathways including glycolysis, fatty acid oxidation and DNA synthesis. Substantial epidemiological evidence indicates that a low magnesium intake is quite common, and that it is associated with diverse pathological conditions, particularly metabolic and inflammatory disorders such as insulin resistance, obesity, diabetes and cardiovascular disease, but also to osteoporosis, cancer and hypertension.

Recent research has highlighted magnesium’s important role in glucose homeostasis, as supplementation improves insulin sensitivity and regulates beta-cell function, while deficiency exacerbates chronic inflammatory stress, contributing to obesity and the metabolic syndrome. Supplementation reduces serum glucose, increases HDL levels and improves insulin sensitivity, even among those with normal magnesium levels, and in both diabetic and non-diabetic populations. Magnesium also improves postprandial hyperlipidemia, and down-regulates genes related to metabolic and inflammatory pathways. In addition to improving magnesium bioavailability, citrate itself is a mitochondrial substrate and provides an alkaline load. It chelates dietary oxalates, reducing renal stone formation risk.

• Magnesium citrate has been shown to have superior bioavailability to other forms of magnesium, increasing its clinical effectiveness
• Citrate-malate complexes increase mineral absorption, particularly among individuals with reduced gastric acid secretion
• Malic acid supplies an important substrate in the citric acid cycle, contributing to improved energy metabolism
• Conveniently dosed at 150mg per capsule, allowing for easy therapeutic dosing
Ingredients:Each veg-capsule contains:
Medicinal

Magnesium (citrate, malate) 150mg. (Sourced from 750mg of magnesium complex yielding 150mg elemental magnesium.)

Non-Medicinal Ingredients:
Malic acid, vegetarian capsule (carbohydrate gum [cellulose], purified water, titanium dioxide), microcrystalline cellulose and vegetable grade magnesium stearate (lubricant).
Directions:Adults: Take 3 capsules per day or as directed by a healthcare practitioner.
Cautions:Magnesium supplementation is contraindicated in individuals with impaired kidney function, as well as those with heart blocks, such as atrioventricular or bifascicular blocks. Some people may experience diarrhea. Do not use if safety seal is broken. Keep out of reach of children.

S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

• Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity
• Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form
• Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption
• 200mg SAMe per tablet, allows for flexible dose titration
• Sourced from the highest quality Italian Isoactive SAMe available on the market
• Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations
• Suitable for vegetarians/vegans

Each tablet contains:
Medicinal ingredient:
S-Adenosyl-L-Methionine (SAMe) 200mg.

Non-Medicinal Ingredients:
Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, talc, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides, yellow iron oxide), glyceryl behenate, vegetable grade magnesium stearate (lubricant), silica and sodium starch glycolate.

Adults: SAMe should always be taken on an empty stomach.For mood balance: Take 1-4 tablets 2 times per day or as directed by a healthcare practitioner. For osteoarthritic pain: 1-3 tablets 2 times per day or as directed by a healthcare practitioner. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.

If you are taking antidepressants, hepatotoxic drugs or monoamine oxidase (MAO) inhibitors, consult a healthcare practitioner prior to taking SAMe in place of or in addition to those medications. Not recommended for use in children. Do not use if you are pregnant or breastfeeding. Do not take at night as SAMe may cause anxiety, restlessness and insomnia. People with bipolar disorder (manic-depressive illness) should not use SAMe unless under medical supervision. Possible side effects are: mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, flatulence), anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. Keep out of reach of children.

Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA, as well as the conversion of homocysteine to methionine by methionine synthase, which is then converted into S-adenosylmethionine. A B12 deficiency causes impairments in both of these pathways, disrupting neurological function, including poor formation of myelin nerve sheaths, production of toxic levels of homocysteine, and inefficient energy production in all cells.

Cobalamin is also required to remove the methyl group from methyltetrahydrofolate and generate tetrahydrofolate, a necessary step in DNA synthesis. As a consequence, B12 deficiency affects the growth, function, and repair of all cells, the most apparent sign of which is megaloblastic anemia, caused by inhibited mitosis of red blood cells. Some individuals, especially those with malabsorption or low dietary intake, are at higher risks for a B12 deficiency. B12 in sublingual form, at a dose of 1000 mcg per day bypasses active absorption routes, and can restore normal B12 levels even in those with pernicious anemia and/or impaired absorptive capacity.

• Lowers homocysteine levels for protective cardiovascular benefits 
• Superior to the more common form, cyanocobalamin as cyanocobalamin does not convert to enough methylcobalamin to correct some forms of anemia, neurological defects and aging
• Methylcobalamin is the active form of vitamin B12 for maximum benefit 
• Sublingual tablets allow for fast acting delivery system directly into blood stream

Adults: Take 1 tablet per day or as directed by a healthcare practitioner. Dissolve under the tongue.
Cautions:Supplemental folic acid may mask a B12 deficiency, which should be ruled out, and folic acid and increased potassium intake is recommended with B12 therapy. B12 is considered safe in pregnant and lactating women, and may be indicated in children with a low dietary intake. Do not use if safety seal is broken. Keep out of reach of children.